美西拉宗
中文名称 | 美西拉宗 |
---|---|
中文同义词 | 美西拉宗;化合物 T16353 |
英文名称 | Meseclazone |
英文同义词 | 3,3a-Dihydro-7-chloro-2-methyl-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one;7-Chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one;W-2395;NSC297623;Meseclazone;7-chloro-2-methyl-3,3a-dihydro-2H-[1,2]oxazolo[3,2-b][1,3]benzoxazin-9-one;2H,9H-Isoxazolo[3,2-b][1,3]benzoxazin-9-one, 7-chloro-3,3a-dihydro-2-methyl- |
CAS号 | 29053-27-8 |
分子式 | C11H10ClNO3 |
分子量 | 239.65 |
EINECS号 | |
相关类别 | |
Mol文件 | 29053-27-8.mol |
结构式 | ![]() |
美西拉宗 性质
熔点 | 148°C |
---|---|
沸点 | 131.8°C (rough estimate) |
密度 | 1.3213 (rough estimate) |
折射率 | 1.5800 (estimate) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | -3.18±0.40(Predicted) |
Meseclazone inhibits collagen-induced aggregation 1 and 4 hr after oral administration. Intravenous administration of Meseclazone and other nonsteroidal anti-inflammatory drugs caused a dose-dependent inhibition of bronchoconstriction resulting in the following order of descending potency: isoproterenol congruent to indomethacin greater than fenoprofen greater than tolmetin greater than aspirin greater than naproxen congruent to ibuprofen greater than phenylbutazone greater than diflunisal greater than Meseclazone greater than 5-CSA.