Company Name: |
Zhejiang Huida Biotech Co., LTD
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Tel: |
0571-89903882 13626641628 |
Email: |
jiangnan@huidabiotech.com |
Products Intro: |
Product Name:Ascofuranone CAS:38462-04-3 Purity:99% HPLC Package:10mg;100mg;1g;10g;100g
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Company Name: |
Zhejiang Huida Biotech Co., LTD
|
Tel: |
0571-0571-89903882 15990081639 |
Email: |
sunshixuan@huidabiotech.com |
Products Intro: |
Product Name:Ascofuranone CAS:38462-04-3 Purity:99% HPLC Package:10mg;100mg;1g;10g;100g
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:Ascofuranone CAS:38462-04-3 Purity:详情请点击官网 Package:1 mg
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| ascofuranone Basic information |
Product Name: | ascofuranone | Synonyms: | ascofuranone;2-Methyl-3-chloro-4,6-dihydroxy-5-[(2E,6E)-3-methyl-7-[(2S)-4-oxo-5,5-dimethyltetrahydrofuran-2-yl]-2,6-octadienyl]benzaldehyde;3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(S)-tetrahydro-5,5-dimethyl-4-oxofuran-2-yl]-2,6-octadienyl]benzaldehyde;Ascofranone;Ascofuranon;(-)-Ascofuranone;Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]- | CAS: | 38462-04-3 | MF: | C23H29ClO5 | MW: | 420.93 | EINECS: | | Product Categories: | | Mol File: | 38462-04-3.mol | |
| ascofuranone Chemical Properties |
Melting point | 84 °C | Boiling point | 581.2±50.0 °C(Predicted) | density | 1?+-.0.06 g/cm3(Predicted) | pka | 6.32±0.50(Predicted) | color | Needles from Me2CO/hexane |
Toxicity | LD50 ipr-rat: 1350 mg/kg JANTAJ 26,681,73 |
| ascofuranone Usage And Synthesis |
Uses | (-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice. | Definition | ChEBI: Ascofuranone is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an antilipemic drug, a fungal metabolite and an antiprotozoal drug. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a tetrahydrofuranone. It is a conjugate acid of an ascofuranone(1-). | Safety Profile | Moderately toxic byintraperitoneal route. Whenheated to decomposition it emits toxic fumes of Cl-. |
| ascofuranone Preparation Products And Raw materials |
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