延命草素
中文名称 | 延命草素 |
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中文同义词 | 延命草素;延命素;延命素,延命草素 |
英文名称 | enmein |
英文同义词 | enmein;Isodonin |
CAS号 | 3776-39-4 |
分子式 | C20H26O6 |
分子量 | 362.42 |
EINECS号 | |
相关类别 | 中药对照品;对照品;二萜;标准品 -中药标准品 |
Mol文件 | 3776-39-4.mol |
结构式 |
延命草素 性质
熔点 | 274-276℃ (Decomposition) (ethanol ) |
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沸点 | 610.3±55.0 °C(Predicted) |
密度 | 1.37±0.1 g/cm3(Predicted) |
酸度系数(pKa) | 12.66±0.60(Predicted) |
Enmein shows significant inhibitory effect toward K562 with an IC 50 value ranging from 3.2 μg/ml to 8.2 μg/ml. Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml. Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%.
Cell Viability Assay
Cell Line: | Splenic lymphocyte cells |
Concentration: | 3.13, 6.25, 12.5, 25 μg/ml |
Incubation Time: | 48 hours |
Result: | Exhibited an IC 50 value of 17 μg/ml in splenic lymphocytes. |
Cell Cycle Analysis
Cell Line: | Splenic lymphocyte cells |
Concentration: | 5.5 μg/ml, 11 μg/ml, 22 μg/ml |
Incubation Time: | 48 hours |
Result: | Caused S stage cells and G2/M stage cells decreased. |
Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression.
Animal Model: | Balb/c mice |
Dosage: | 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg |
Administration: | Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days |
Result: | Had inhibitory effect on IL-2 release in blood. |