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| | 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Basic information |
| Product Name: | 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride | | Synonyms: | 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-,monohydrochloride (Varenicline Hcl);Varenicline hydrochloride;6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride;5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, hydrochloride (1:1);7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride;6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride | | CAS: | 230615-23-3 | | MF: | C13H14ClN3 | | MW: | 247.73 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 230615-23-3.mol | ![6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Structure](CAS/GIF/230615-23-3.gif) |
| | 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | color | Light yellow to khaki |
| | 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Usage And Synthesis |
| Uses | Varenicline Hydrochloride is a useful nicotine binding inhibitor. | | Biological Activity | varenicline hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].varenicline hydrochloride has been reported to potently inhibit nachr binding with the ki values of 0.12±0.02 nm and 0.14±0.01 nm for α6β2* nachr and α4β2* nachr, respectively in rat striatum, 0.13±0.01 nm and 0.19±0.11 nm forα6β2* nachr and α4β2* nachr, respectively in monkey striatum. in addition, varenicline hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nachrs compared with nicotine with the ec50 values of 0.007 and 0.086μm, respectively in rat striatum [1]. | | references | [1] bordia t1, hrachova m, chin m, mcintosh jm, quik m. varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. j pharmacol exp ther. 2012 aug;342(2):327-34. doi: 10.1124/jpet.112.194852. epub 2012 may 1. |
| | 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Preparation Products And Raw materials |
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