Benzilic acid

Benzilic acid Basic information

Product Name:	Benzilic acid
Synonyms:	BENZILIC ACID extrapure;Benzilic acidDiphenylglycolic acid;TrospiuM Chloride Related CoMpound A;Trospium Chloride Related Compound A (20 mg) (Benzilic Acid) (Internationally Restricted Sales Item);BENZILIC ACID FOR SYNTHESIS 1 KG;BENZILIC ACID FOR SYNTHESIS 250 G;Benzeneacetic acid,a-hydroxy-a-phenyl-;Trospium Chloride Related Compound A (20 mg) (Benzilic Acid) (International Restricted Sales Item)
CAS:	76-93-7
MF:	C14H12O3
MW:	228.25
EINECS:	200-993-2
Product Categories:	Pharmaceutical Intermediates;Organics;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:	76-93-7.mol

Benzilic acid Chemical Properties

Melting point	149-151 °C(lit.)
Boiling point	180 °C
density	1.28
refractive index	1.5805 (estimate)
Fp	180°C/22mm
storage temp.	Store below +30°C.
solubility	1.41g/l (experimental)
form	Powder
pka	pKa (25°): 3.036
color	White to cream-white
Water Solubility	1.41 g/L (25 ºC)
Merck	14,1080
BRN	521402
Stability:	Stable. Incompatible with strong oxidizing agents. Combustible.
LogP	2.300
CAS DataBase Reference	76-93-7(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetic acid, «alpha»-hydroxy-«alpha»-phenyl-(76-93-7)
EPA Substance Registry System	Benzilic acid (76-93-7)

Safety Information

MSDS Information

Provider	Language
2-Hydroxy-2,2-diphenylacetic acid	English
SigmaAldrich	English
ALFA	English

Benzilic acid Usage And Synthesis

Chemical Properties	white powder
Uses	Benzilic Acid is an impurity of Trospium (T892800), a tropine derivative with anticholinergic activity and a antiispasmodic agent.
Definition	ChEBI: Benzilic acid is a 2-hydroxy monocarboxylic acid.
Synthesis Reference(s)	The Journal of Organic Chemistry, 29, p. 1631, 1964 DOI: 10.1021/jo01029a509
Safety Profile	Moderately toxic by subcutaneousroute. Slightly toxic by ingestion. When heated todecomposition it emits acrid smoke and irritating vapors.
Purification Methods	Crystallise benzilic acid from *benzene (ca 6mL/g), or hot H2O. [Beilstein 10 IV 1256.]

Benzilic acid Preparation Products And Raw materials

Raw materials	Potassium bromate-->Benzil
Preparation Products	Methyl benzilate-->2,2-Diphenylacetic acid-->BENACTYZINE HYDROCHLORIDE-->Bromopropylate-->Methylbenactyzine bromide-->1,2-BENZENEDISULFONYL DICHLORIDE-->Methyl cyclohexylphenylglycolate-->9-Carboxyfluorene

Tag:Benzilic acid(76-93-7) Related Product Information

Glycolic acid Stearic acid POLY(2-HYDROXYACETIC ACID) 1,5-Diphenylcarbazide Ethyl glycolate Citric acid CHLOROPHOSPHONAZO III Chlorodiphenylphosphine 2,2-Diphenylacetic acid Bis(2-ethylhexyl) phthalate Dichlorodiphenylsilane Sodium glycolate 3,4-Dihydroxyphenylacetic acid Potassium hydrogen phthalate 2-Hydroxyphenylacetic acid Diphenyl ether 1,3-Diphenyl-2-thiourea m-Phenylenediamine

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