N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
中文名称 | N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐 |
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中文同义词 | N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐;W-7盐酸盐;N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐;15366217190N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐;N-(6-氨基己基)-5-氯萘-1-磺酰胺盐酸盐 |
英文名称 | W-7 HYDROCHLORIDE |
英文同义词 | OMEGA-7 HYDROCHLORIDE;N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE;W-7;W-7 HYDROCHLORIDE;N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride |
CAS号 | 61714-27-0 |
分子式 | C16H22Cl2N2O2S |
分子量 | 377.33 |
EINECS号 | |
相关类别 | 合成;All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Calcium signaling |
Mol文件 | 61714-27-0.mol |
结构式 | ![]() |
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐 性质
熔点 | 220-222 °C |
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储存条件 | -20°C |
溶解度 | 甲醇:25 mg/mL,澄清,无色 |
形态 | 类白色结晶固体 |
颜色 | 白色至类白色 |
BRN | 6030174 |
CAS 数据库 | 61714-27-0(CAS DataBase Reference) |
IC50: 28 μM (Phosphodiesterase) and 51 µM (Myosin light chain kinase)
W-7 is distributed mainly in the cytoplasm, and inhibits proliferation of Chinese hamster ovary K1 (CHO-K1) cells. W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle.
W-7 (100 μM) exhibits a similar extent of antagonism between the contractile responses to carbachol and KCl. The increase in myosin light chain (P-LC) phosphate content in response to 1-min stimulation with 10 μM carbachol is inhibited by W-7. W-7 antagonizes the smooth muscle contraction through the inhibition of the initial increase in the P-LC phosphorylation.
Treatment with W-7 results in the dose-dependent inhibition of cell proliferation in various human multiple myeloma cell lines. W-7 induces G1 phase cell cycle arrest by downregulating cyclins and upregulating p21cip1. W-7 induces apoptosis via caspase activation; this occurred partly through the elevation of intracellular calcium levels and mitochondrial membrane potential depolarization and through inhibition of the STAT3 phosphorylation and subsequent downregulation of Mcl-1 protein.
W-7 competitively inhibits Ca
2+
/calmodulin-dependent phosphodiesterase with a K
i
value of 300 μM.
W-7 (3 mg/kg; intraperitoneal injection; on 5 consecutive days per week; female BALB/c nu mice) treatment significantly reduces tumor growth in a murine MM model.
Animal Model: | Female BALB/c nu mice (6-week-old) injected with RPMI 8226 cells |
Dosage: | 3 mg/kg |
Administration: | Intraperitoneal injection; on 5 consecutive days per week |
Result: | Significantly reduced tumor growth in a murine MM model. |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100912 | W-7 hydrochloride | 5 mg | 480元 | |
2024/08/19 | HY-100912 | N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐 W-7 hydrochloride | 61714-27-0 | 10mM * 1mLin DMSO | 528元 |