Zoledronate disodium tetrahydrate

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Products Intro: Product Name:zoledronate disodium tetrahydrate
CAS:165800-07-7
Purity:0.99 Package:1kg
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Products Intro: Product Name:ZOLEDRONATE DISODIUM TETRAHYDRATE
CAS:165800-07-7
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Products Intro: Product Name:Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate
CAS:165800-07-7
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Products Intro: Product Name:Zoledronic Acid Disodium Salt Tetrahydrate
CAS:165800-07-7
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Products Intro: Product Name:Zoledronic Acid DisodiuM Salt Tetrahydrate
CAS:165800-07-7
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Zoledronate disodium tetrahydrate Basic information
Product Name:Zoledronate disodium tetrahydrate
Synonyms:ZOLEDRONATE DISODIUM, TETRAHYDRATE;ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE;Zoledronate Disodium, CGP-42446A;(1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate;CGP-42446A;Zoledronate DisodiuM (C5H8N2Na2O7P24H2O);Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate;Disodium salt tetrahydrate
CAS:165800-07-7
MF:C5H13N2NaO8P2
MW:314.1
EINECS:
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:165800-07-7.mol
Zoledronate disodium tetrahydrate Structure
Zoledronate disodium tetrahydrate Chemical Properties
Melting point 305-307°C
storage temp. Sealed in dry,Room Temperature
solubility Methanol (Slightly, Heated, Sonicated), Water (Slightly, Heated)
form Solid
color White to Off-White
Safety Information
MSDS Information
Zoledronate disodium tetrahydrate Usage And Synthesis
DescriptionZoledronate was introduced in Canada as a lyophilized powder in vials for infusion as solution in the treatment of tumor-induced hypercalcemia. This third-generation bisphosphonate can be obtained by reaction of 2-(1-imidazolyl)acetic acid hydrochloride with phosphorous trichloride followed by hydrolysis in concentrated hydrochloric acid, Zoledronate originated from a medicinal chemistry program started at Novartis, Switzerland in 1986 and aimed at discovering a follow-up to pamidronate for the treatment of osteoporosis and metastatic bone disease. It has highly potent inhibitory effect on hypercalcemia induced by vitamin Ds both in vitro in mouse calvarial cultures and in viva in the thyroparathyroidectomized rat. It is respectively 100 and 850-fold more potent than pamidronate in the former and latter tests. Clinically, it was demonstrated that zoledronate achieved normalized serum calcium concentrations in a significantly higher percentage of cancer patients compared to pamidronate. The 5 minute infusion with zoledronate was more convenient than the 2 hour infusion necessary with pamidronate.
Chemical PropertiesWhite Crystalline Powder
OriginatorNovartis (Switzerland)
UsesA biphosphonate bone resorption inhibitor.
Brand nameZometa
Zoledronate disodium tetrahydrate Preparation Products And Raw materials
Tag:Zoledronate disodium tetrahydrate(165800-07-7) Related Product Information
Sodium Monofluorophosphate Zofenoprilat Zoledronic acid hydrate [15N2,13C2]-Zoledronic Acid Zoledronic Acid Trihydrate Zoledronic-d3 Acid Ethylenediaminetetraacetic acid disodium salt Imidazole Zoledronic acid Sodium Phosphate, Dibasic Pamidronate disodium salt CHLOROPHOSPHONAZO III 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 1-Hydroxyethylidene-1,1-diphosphonic acid 1-Hydroxyethanediphosphonic acid sodium salt Etidronic acid monohydrate Zoledronate disodium tetrahydrate Β-GLYCEROPHOSPHATE, DISODIUM SALT