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| N-Boc-trans-4-Hydroxy-L-proline methyl ester Basic information |
| N-Boc-trans-4-Hydroxy-L-proline methyl ester Chemical Properties |
Melting point | 92-96 °C (lit.) | alpha | -65 º (c=1 CHCl3) | Boiling point | 132°C/0.05mmHg(lit.) | density | 1.216±0.06 g/cm3(Predicted) | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | solubility | Soluble in chloroform, dichloromethane and ethyl acetate. | form | Crystalline Powder | pka | 14.27±0.40(Predicted) | color | White to light beige | optical activity | [α]20/D -65°, c = 1% in chloroform | InChI | InChI=1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8+/m1/s1 | InChIKey | MZMNEDXVUJLQAF-SFYZADRCSA-N | SMILES | N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@H]1C(OC)=O | LogP | 0.813 at 25℃ | CAS DataBase Reference | 74844-91-0(CAS DataBase Reference) |
| N-Boc-trans-4-Hydroxy-L-proline methyl ester Usage And Synthesis |
Chemical Properties | Clear Colourless Oil | Uses | It is used in the synthesis of For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold. | Uses | (2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester
roline scaffold. | Uses | A potential iNOS inhibitor. |
| N-Boc-trans-4-Hydroxy-L-proline methyl ester Preparation Products And Raw materials |
Raw materials | trans-4-Hydroxy-L-proline methyl ester hydrochloride-->(2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate-->Boc-Hyp-OH-->Trans-4-Hydroxy-L-proline Hydrochloride-->(S)-N-Boc-allylglycine-->(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate-->(TRIMETHYLSILYL)DIAZOMETHANE-->tert-butyl azidoformate-->L-Hydroxyproline | Preparation Products | N-Boc-4-oxo-L-Proline methyl ester-->2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)--->(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide-->1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine-->N-BOC-cis-4-fluoro-L-proline-->(2S,4S)-1-tert-butyl 2-methyl 4-chloropyrrolidine-1,2-dicarboxylate-->(2S,4R)-1-BOC-4-BENZYLOXY-PYRROLIDINE-2-DICARBOXYLIC ACID METHYL ESTER |
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