Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
CAS:73029-73-9
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-32668
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:CyPPA
CAS:73029-73-9
Package:10 mg;100 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
CAS:73029-73-9
Purity:98.8%min emma@coreychem.com Package:1KG;2.18USD
Company Name: RR Scientific LLC
Tel: +86-13917743231
Email: sales@rrscientific.com
Products Intro: Product Name:N-cyclohexyl-6-methyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine
CAS:73029-73-9
Purity:0.98+ Package:100 g; 500 g; 1 kg; 5 kg; 10 kg;10kg+
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:CyPPA
CAS:73029-73-9
Purity:98%+ Package:100mg,1g,2g,5g,10g
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Basic information
Product Name:Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
Synonyms:Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine;N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine;N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid;4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-;N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl);N-cyclohexyl-6-methyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine
CAS:73029-73-9
MF:C16H23N5
MW:285.39
EINECS:
Product Categories:
Mol File:73029-73-9.mol
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Structure
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Chemical Properties
Boiling point 512.2±42.0 °C(Predicted)
density 1.23
storage temp. 2-8°C
solubility DMSO: >10mg/mL
pka4.19±0.10(Predicted)
form solid
color white
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37
WGK Germany 3
MSDS Information
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Usage And Synthesis
UsesCyPPA is a positive SK3/SK2 modulator that reduces the activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methyl phenidate.
UsesCyPPA has been used:
  • to test its inhibitory functionality on melanogenesis
  • as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
  • in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells

Biological ActivityActivator of small conductance Ca 2+ -activated K + channels that displays selectivity for SK2 and SK3 channels (EC 50 values are 5.6 and 14 μ M for SK3 and SK2 respectively). Displays no activity at SK1 and IK channels.
Biochem/physiol ActionsCyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.
storage+4°C
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Preparation Products And Raw materials
Tag:Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine(73029-73-9) Related Product Information
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