- Molsidomine
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- $10.00 / 1kg
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2024-08-15
- CAS:25717-80-0
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20 tons
- molsidomine
-
- $0.00 / 1Kg
-
2024-04-09
- CAS:25717-80-0
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- Molsidomine
-
- $0.00 / 1KG
-
2023-09-06
- CAS:25717-80-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| Molsidomine Basic information |
Product Name: | Molsidomine | Synonyms: | ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate;CORVATON;N-Carboxy-3-morpholino-syndone imine ethyl ester;corvasal;SIN-10;n-carboxy-3-morpholinosynonimine ethyl ester;N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE;N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE | CAS: | 25717-80-0 | MF: | C9H14N4O4 | MW: | 242.23 | EINECS: | 247-207-4 | Product Categories: | Nitric Oxide;API | Mol File: | 25717-80-0.mol | ![Molsidomine Structure](CAS/GIF/25717-80-0.gif) |
| Molsidomine Chemical Properties |
Melting point | 140-141°C | Boiling point | 385.05°C (rough estimate) | density | 1.3186 (rough estimate) | refractive index | 1.6300 (estimate) | storage temp. | Inert atmosphere,2-8°C | solubility | Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride. | pka | pK (100°) 3.0 ± 0.1 | form | Solid | color | White to Off-White | λmax | 317nm(MeOH)(lit.) | Merck | 14,6234 | CAS DataBase Reference | 25717-80-0(CAS DataBase Reference) |
Hazard Codes | Xn | Risk Statements | 22 | Safety Statements | 36 | WGK Germany | 3 | RTECS | WU7677400 | HS Code | 29349990 | Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi) |
| Molsidomine Usage And Synthesis |
Chemical Properties | White to Off-White Solid | Originator | Corvasal,Hoechst | Uses | Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor. | Definition | ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines. | Manufacturing Process | 1.6 parts by volume of ethyl chloroformate is stirred dropwise into a
suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in
5 parts by volume of pyridine, and the mixture is agitated for a while to allow
reaction to take place. Pyridine is removed from the reaction mixture by
evaporation, and the residue is dissolved in a small amount of water and
extracted with chloroform several times. The extract is dehydrated by adding
anhydrous magnesium sulfate and subjected to filtration. Chloroform is
removed from the filtrate by distillation, crude crystals being obtained.
Recrystallization of the crude crystals from toluene gives 0.6 part by weight of
3-morpholino-N-carboethoxysydnonimine having a melting point of 140°-
141°C. Yield 51%. | Brand name | Corvaton (Hoechst-Roussel). | Therapeutic Function | Coronary vasodilator |
| Molsidomine Preparation Products And Raw materials |
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