Mitoquinone mesylate manufacturers
- Mitoquinone mesylate
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- $0.00 / 1KG
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2024-11-01
- CAS:845959-50-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5,000KG
- Mitoquinone mesylate
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- $1.00 / 1KG
-
2020-01-02
- CAS:845959-50-4
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | Mitoquinone mesylate Basic information |
| Product Name: | Mitoquinone mesylate | | Synonyms: | Mitoquinone mesylate;MitoQ;10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium,methanesulfonate;Mitoquinone mesylate (Mitoquinone methanesulfonate;MitoQ mesylate;MitoQ10 mesylate;Mitoquinol Mesylate;Mitoquinone mesylate, ethanol solution | | CAS: | 845959-50-4 | | MF: | C38H47O7PS | | MW: | 678.814341 | | EINECS: | 000-010-1 | | Product Categories: | | | Mol File: | 845959-50-4.mol |  |
| | Mitoquinone mesylate Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO. | | form | waxy solid | | color | Orange | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | Mitoquinone mesylate Usage And Synthesis |
| Description | Mitoquinone mesylate (845959-50-4) is a mitochondria-targeted antioxidant.? Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2,3 Protects pancreatic β-cells against oxidative stress and improves insulin secretion.4 Inhibits respiratory syncytial virus (RSV) production via lowering of mitochondrial ROS levels.5 Cell permeable. | | Uses | Mitoquinone Mesylate is used in the transport and metabolism of some cationic ubiquinone antioxidants. | | in vivo | Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10 mg/kg (dose 1)[2]. | | References | 1.Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674
2.McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703
3.Young and Franklin, (2019), The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice; Cell Neurosci. 101 103409
4.Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic b-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
5.MengJie et al. (2019), Subversion of Host Cell Mitochondria by RSV to Favor Virus Production in Dependent on Inhibition of Mitochondrial Complex I and ROS Generation; Cells 8 1417 |
| | Mitoquinone mesylate Preparation Products And Raw materials |
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