米托蒽醌甲磺酸盐
中文名称 | 米托蒽醌甲磺酸盐 |
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中文同义词 | 米托蒽醌甲磺酸盐;米托醌甲磺酸盐;甲磺酸米托醌(米托Q10);MITOQ MESYLATE|||米托蒽醌甲磺酸盐|||MITOQ10 MESYLATE;MITOQUINONE MESYLATE米托蒽醌 |
英文名称 | Mitoquinone mesylate |
英文同义词 | Mitoquinone mesylate;MitoQ;10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium,methanesulfonate;Mitoquinone mesylate (Mitoquinone methanesulfonate;MitoQ mesylate;MitoQ10 mesylate;Mitoquinol Mesylate;Mitoquinone mesylate, ethanol solution |
CAS号 | 845959-50-4 |
分子式 | C38H47O7PS |
分子量 | 678.814341 |
EINECS号 | 000-010-1 |
相关类别 | 对照品-杂质对照品 |
Mol文件 | 845959-50-4.mol |
结构式 | ![]() |
米托蒽醌甲磺酸盐 性质
储存条件 | -20°C |
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溶解度 | 溶于二甲基亚砜。 |
形态 | 蜡状固体 |
颜色 | 橙色 |
稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
Target | Value |
mitochondria
() | |
ROS
() |
Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant.The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). The potential protective benefits of Mitoquinone treatment against CS injury are tested initially using MitoSOX Red, a mitochondrial-targeted fluorescent dye that measures mitochondrial superoxide generation. Normal rat kidney (NRK) cells exposed to CS result in a ~2-fold increase in fluorescence due to mitochondrial superoxide compared with untreated cells. Mitoquinone offers significant protection against CS-induced mitochondrial superoxide generation; whereas the control compound DecylTPP does not offer any protection. Mitoquinone treatment markedly decreases mitochondrial superoxide generation, whereas kidneys treated with DecylTPP have comparable levels of mitochondrial superoxide to kidneys exposed to CS alone.
Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10 mg/kg (dose 1).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100116A | 米托蒽醌甲磺酸盐 Mitoquinone mesylate | 845959-50-4 | 5mg | 1100元 |
2024/08/19 | HY-100116A | 米托蒽醌甲磺酸盐 Mitoquinone mesylate | 845959-50-4 | 10mM * 1mLin DMSO | 1643元 |