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NVP-HSP990(HSP990)

NVP-HSP990(HSP990) Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:HSP-990
CAS:934343-74-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:HSP-990
CAS:934343-74-5
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Changzhou PBpharmaceutical R&D Co.,Ltd
Tel: 0519-83990708
Email: info@pbpharm.com
Products Intro: Product Name:HSP-990
CAS:934343-74-5
Purity:98% Package:100MG,500MG,1G,5G,25G,100G Remarks:in stock or customized product
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:NVP-HSP990(HSP990)
CAS:934343-74-5
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:NVP-HSP990(HSP990)
CAS:934343-74-5
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

NVP-HSP990(HSP990) manufacturers

  • NVP-HSP990(HSP990)
  • NVP-HSP990(HSP990) pictures
  • $0.00 / 1KG
  • 2022-10-14
  • CAS:934343-74-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1Ton
NVP-HSP990(HSP990) Basic information
Product Name:NVP-HSP990(HSP990)
Synonyms:NVP-HSP990(HSP990);HSP-990;NVP-HSP990;(R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one;(7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one;HSP990 (NVP-HSP990);(7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d;NVP-HSP990(HSP990) USP/EP/BP
CAS:934343-74-5
MF:C20H18FN5O2
MW:379.39
EINECS:
Product Categories:Inhibitors
Mol File:934343-74-5.mol
NVP-HSP990(HSP990) Structure
NVP-HSP990(HSP990) Chemical Properties
density 1.332
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO
form solid
color Off-white to yellow
Safety Information
HS Code 29339900
MSDS Information
NVP-HSP990(HSP990) Usage And Synthesis
UsesNVP-HSP990 is an orally available HSP90 inhibitor.
Biological Activityhsp990 (nvp-hsp990) is a potent and selective inhibitor of hsp90 with ic50 values of 0.6, 0.8 and 8.5 nm for hsp90α, hsp90β and grp94, respectively [1].heat shock protein 90 (hsp90) is a chaperone protein that stabilizes proteins against heat stress, assists proteins to fold properly and aids in protein degradation. also, hsp90 stabilizes proteins required for tumor growth.hsp990 (nvp-hsp990) is a potent and selective hsp90 inhibitor. nvp-hsp990 bound to the n-terminal atp-binding domain of hsp90. nvp-hsp990 inhibited trap1 atpase activity by 90% with ic50 value of 320 nm. in gtl-16 cells, nvp-hsp990 destabilized the hsp90-p23 complex in a concentration- and time-dependent way. also, nvp-hsp990 decreased c-met with ec50 value of 37 nm and induced hsp70 with ec50 value of 20 nm. nvp-hsp990 inhibited erk and akt phosphorylation with ec50 values of 11 and 6 nm respectively and thus inhibited erk and akt activation. in five human tumor cell lines, nvp-hsp990 inhibited cell growth with gi50 values of 4-40 nm [1]. in glioma tumor-initiating cells, nvp-hsp990 inhibited cell growth with ic50 value of 10-500 nm in a dose-dependent way and reduced cdk2 and cdk4, thus disrupting cell-cycle control [2].in the gtl-16 gastric cancer mice model, nvp-hsp990 exhibited antitumor efficacy [1].
references[1]. menezes dl, taverna p, jensen mr, et al. the novel oral hsp90 inhibitor nvp-hsp990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. mol cancer ther, 2012, 11(3): 730-739.
[2]. fu j, koul d, yao j, et al. novel hsp90 inhibitor nvp-hsp990 targets cell-cycle regulators to ablate olig2-positive glioma tumor-initiating cells. cancer res, 2013, 73(10): 3062-3074.
NVP-HSP990(HSP990) Preparation Products And Raw materials
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