3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐
| 中文名称 | 3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐 |
|---|---|
| 中文同义词 | 3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐;盐酸MTEP;盐酸二甲基乙酰胺 |
| 英文名称 | MTEP |
| 英文同义词 | 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);MTEP HCl;3-((2-Methyl-1;3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride |
| CAS号 | 1186195-60-7 |
| 分子式 | C11H9ClN2S |
| 分子量 | 236.72056 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1186195-60-7.mol |
| 结构式 | ![3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐 结构式](CAS/20180808/GIF/1186195-60-7.gif) |
3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐 性质
| 熔点 | 154-156℃ (isopropanol ) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 颜色 | 淡奶油 |
MTEP hydrochloride 是非竞争性的 mGlu5 拮抗剂，IC50 和 Ki 分别为 5 nM 和16 nM。MTEP hydrochloride 产生抗帕金森病样作用。
|
mGluR5 5 nM (IC 50 ) |
mGluR5 16 nM (Ki) |
MTEP hydrochloride (3-5 mg/2 ml/kg; i.p.) inhibits the catalepsy induced (0.5 mg/kg/2 ml; i.p.) by this neuroleptic.
| Animal Model: | Male Wistar rats (weighing 215-315 g) |
| Dosage: | 3 or 5 mg/2 ml/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited the catalepsy induced by this neuroleptic. |