石斛酚
| 中文名称 | 石斛酚 |
|---|---|
| 中文同义词 | 石斛酚标准品;5-[2-(3-羟基-5-甲氧基苯基)乙基]-2-甲氧基苯酚;5-(3-羟基-5-甲氧基苯乙基)-2-甲氧基苯酚;3,3'-二羟基-4',5-二甲氧基联苄;石斛酚(3′,3-二羟基石斛酚);3',3-二羟基石斛酚 |
| 英文名称 | Dendrophenol |
| 英文同义词 | Gigantic;Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol);Phenol, 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-;inhibit,Wnt,Gigantol,Inhibitor;5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol;Gigantol isomer-1;Dendrobium phenol |
| CAS号 | 67884-30-4 |
| 分子式 | C16H18O4 |
| 分子量 | 274.31 |
| EINECS号 | |
| 相关类别 | 标准品;中药对照品;其它酚类 |
| Mol文件 | 67884-30-4.mol |
| 结构式 |  |
石斛酚 性质
| 沸点 | 454.1±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.204±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥160mg/mL（583.28mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.63±0.10(Predicted) |
| 颜色 | 白色至米白色 |
Gigantol是一种来自几种药用兰花的联苄基化合物。 Gigantol 具有抗肿瘤活性。Gigantol 是 Wnt/β-catenin 通路的抑制剂。
Wnt
Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 µM.
LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats.
化学性质
类白色结晶体，易溶于甲醇、乙酸乙酯，几乎不溶于水，来源于金钗石斛。用途
石斛酚具有免疫调节、抗肿瘤、降血脂、降血糖的作用。用途
用于含量测定/鉴定/药理实验等。