GSK 525768A
| 中文名称 | GSK 525768A |
|---|---|
| 中文同义词 | 化合物 T11472;BROMODOMAIN抑制剂(GSK 525768A) |
| 英文名称 | GSK-525768A |
| 英文同义词 | GSK 525768A;GSK525768A;GSK-525768A;(4R)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide;GSK-525768;4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, 6-(4-chlorophenyl)-N-ethyl-8-methoxy-1-methyl-, (4R)-;GSK525768A; GSK-525768A |
| CAS号 | 1260530-25-3 |
| 分子式 | C22H22ClN5O2 |
| 分子量 | 423.9 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1260530-25-3.mol |
| 结构式 |  |
GSK 525768A 性质
| 熔点 | 140-145℃ |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 15.71±0.46(Predicted) |
| 颜色 | 浅黄至黄色 |
GSK 525768A 是 GSK525762A 的无活性对映体。GSK 525768A 对 BET 没有活性。
GSK 525768A has no activity towards BET. GSK 525768A (GSK525768A) is the (R)-enantiomer of GSK525762A. GSK525762A is shown to regulate levels of the high-density lipid protein apolipoprotein A1 (APOA1) in assays monitoring APOA1 release in liver cells, whereas the (R)-enantiomer (GSK 525768A) has no effect. GSK 525768A directly engages the protein module by forming hydrogen bonds with the conserved asparagine residue in a way that mimics the binding mode of acetylated lysine; this usually results in the binding of the inhibitor deeper within the acetylated lysine binding site but without displacing the conserved water molecules that are present at the bottom of the acetyl-lysine binding cavity.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-13032A | GSK 525768A GSK 525768A | 1260530-25-3 | 2mg | 2170元 |
| 2024/04/30 | HY-13032A | GSK 525768A GSK 525768A | 1260530-25-3 | 10mM * 1mLin DMSO | 3036元 |