ApovincaMinic Acid Hydrochloride Salt
| 中文名称 | ApovincaMinic Acid Hydrochloride Salt |
|---|---|
| 中文同义词 | |
| 英文名称 | ApovincaMinic Acid Hydrochloride Salt |
| 英文同义词 | ApovincaMinic Acid Hydrochloride Salt;Vinpocetine Carboxylic Acid HCl (Apovincaminic Acid HCl);Vinpocetine Carboxylic Acid HCl |
| CAS号 | 72296-47-0 |
| 分子式 | C20H23ClN2O2 |
| 分子量 | 358.87 |
| EINECS号 | |
| 相关类别 | Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 72296-47-0.mol |
| 结构式 |  |
ApovincaMinic Acid Hydrochloride Salt 性质
| 熔点 | >236°C (dec.) |
|---|---|
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | DMSO（微溶）、甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 白色 |
| 稳定性 | 吸湿性 |
Apovincaminic acid hydrochloride salt 是 Vinpocetine (VP) 的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminic acid hydrochloride salt 具有神经保护作用。
Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation.
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats.
| Animal Model: | Male Harlan‐Wistar rats (300-400 g) are injected NMDA |
| Dosage: | 10 mg/kg |
| Administration: | I.p. twice daily for 4 days |
| Result: |
Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-133813A | Apovincaminic acid hydrochloride salt | 1 mg | 500元 | |
| 2024/04/30 | HY-133813A | ApovincaMinic Acid Hydrochloride Salt Apovincaminic acid hydrochloride salt | 72296-47-0 | 5mg | 1100元 |