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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PF-06424439 methanesulfonate
CAS:1469284-79-4
Purity:98.00% Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:PF 06424439
CAS:1469284-79-4
Package:100mg;1g
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:PF-06424439
CAS:1469284-79-4
Purity:95% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:PF 06424439
CAS:1469284-79-4
Purity:>=98%(HPLC) Package:$48.9/1mg;$68.9/5mg;$117.9/10mg;$246.9/25mg;Bulk package Remarks:98%(HPLC)
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
Tel: 400-400-6206333 18521732826
Email: market@aladdin-e.com
Products Intro: Product Name:PF 06424439
CAS:1469284-79-4
Purity:>=98%(HPLC) Package:5mg/RMB 1380.90;10mg/RMB 2492.90;1mg/RMB 710.90
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Basic information
Product Name:[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
Synonyms:[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;PF-06424439;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate
CAS:1469284-79-4
MF:C23H30ClN7O4S
MW:536.0468
EINECS:
Product Categories:
Mol File:1469284-79-4.mol
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Structure
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Chemical Properties
storage temp. room temp
solubility H2O: soluble10mg/mL, clear
form powder
color white to light brown
Safety Information
WGK Germany 3
MSDS Information
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Usage And Synthesis
DescriptionPF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.
UsesPF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)?inhibitor:
  • to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
  • to study its effects on HeLa cells
  • to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol ActionsPF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
storageDesiccate at RT
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Preparation Products And Raw materials
Tag:[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate(1469284-79-4) Related Product Information
PF-06700841 tosylate PF-06650833 PF-05089771 (tosylate) PF-06424439 PF-06447475 PF 3644022 PF 04995274 PF-3084014 PF 573228 PF-06882961 PF-5190457 PF-05212384 PF-04691502 1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]- PF 477736