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| | PF 04995274 Basic information |
| Product Name: | PF 04995274 | | Synonyms: | PF 04995274;PF-04995274 >=98% (HPLC);2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-;PF04995274;PF 04995274;4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol;Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like | | CAS: | 1331782-27-4 | | MF: | C23H32N2O6 | | MW: | 432.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1331782-27-4.mol |  |
| | PF 04995274 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM) | | form | A crystalline solid | | color | White to off-white |
| | PF 04995274 Usage And Synthesis |
| Description | PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg. |
| | PF 04995274 Preparation Products And Raw materials |
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