N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN
中文名称 | N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN |
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中文同义词 | (S)-2-((R)-3-([1,1'-联苯]-4-基)-2-(N,3,5-三甲基苯甲酰胺基)丙酰胺基)-3-(1H-吲哚-3-基)丙酸;化合物 T15596;T15596;化合物IRL 2500;IRL-2500,ETB拮抗剂;(S)-2-((R)-3-([1,1'-联苯]-4-基)-2-(N,3,5-三甲基苯甲酰胺基)丙酰胺基)-3-(1H-吲哚-3-基)丙酸 |
英文名称 | IRL-2500 |
英文同义词 | IRL-2500;N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN;((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan;L-Tryptophan, 3-[1,1'-biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-;((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan |
CAS号 | 169545-27-1 |
分子式 | C36H35N3O4 |
分子量 | 573.68 |
EINECS号 | |
相关类别 | Endothelin receptor |
Mol文件 | 169545-27-1.mol |
结构式 |
N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN 性质
沸点 | 893.7±65.0 °C(Predicted) |
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密度 | 1.246±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 | 1eq 中可溶解至 100 毫升氢氧化钠 |
形态 | 粉末 |
酸度系数(pKa) | 3.34±0.10(Predicted) |
颜色 | 白色至浅黄色 |
ET B 1.3 nM (IC 50 ) |
ET A 94 nM (IC 50 ) |
IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat. IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-103460 | N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN IRL 2500 | 169545-27-1 | 1 mg | 761元 |
2024/04/30 | HY-103460 | N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN IRL 2500 | 169545-27-1 | 10mg | 3200元 |