BAM15

BAM15 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:BAM 15
CAS:210302-17-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:BAM 15
CAS:210302-17-3
Purity:>=98% by HPLC Package:100mg Remarks:BOC Sciences also provides custom synthesis services for BAM 15.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BAM 15
CAS:210302-17-3
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;5 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:BAM15
CAS:210302-17-3
Purity:95.0% windy 239
Company Name: Wuhan senwayer century chemical Co.,Ltd
Tel: +undefined-27-86652399 +undefined13627115097
Email: market02@senwayer.com
Products Intro: Product Name:BAM15
CAS:210302-17-3
Purity:99% min Package:1kg

BAM15 manufacturers

  • BAM15
  • BAM15 pictures
  • $0.00 / 1kg
  • 2023-11-27
  • CAS:210302-17-3
  • Min. Order: 1kg
  • Purity: 99% min
  • Supply Ability: 20 tons
BAM15 Basic information
Product Name:BAM15
Synonyms:BAM15;N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;CS-2890;[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine, N5,N6-bis(2-fluorophenyl)-;BAM15 >=98% (HPLC);BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine);inhibit,BAM-15,Inhibitor,BAM 15,BAM15,Mitochondrial Metabolism
CAS:210302-17-3
MF:C16H10F2N6O
MW:340.29
EINECS:201-118-7
Product Categories:
Mol File:210302-17-3.mol
BAM15 Structure
BAM15 Chemical Properties
Boiling point 421.7±55.0 °C(Predicted)
density 1.548±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (35 mg/ml)
pka-2.40±0.50(Predicted)
form powder
color white to beige
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
MSDS Information
BAM15 Usage And Synthesis
DescriptionBAM15 (210302-17-3) is a mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane.2 Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models.3 Reverses diet-induced obesity and insulin resistance in mice.4 Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.5
UsesBAM 15, is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.
Biochem/physiol ActionsBAM15 increases mitochondrial respiration rate and is also found to be less cytotoxic compared to other protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone. Hindered oncogenic MAPK (mitogen-activated protein kinase ) signaling leads to BAM15 induced mitochondrial apoptotic pathway activation.
Enzyme inhibitorThis novel mitochondrial uncoupler (FW = 340.29 g/mol), also named (2- fluorophenyl)-{6-[(2-fluorophenyl)amino]-(1,2,5-oxadiazolo[3,4-e]pyrazin- 5-yl)}amine, exhibits a broad effective range of H+ gradient-dissipating action without affecting plasma membrane electrophysiology. With FCCP as an equipotent positive control, BAM15 was found to be fully able to increase mitochondrial respiration in the presence of oligomycin over a broader concentration range than FCCP in both myoblasts and hepatocytes. BAM15 and FCCP had similar effects on mitochondrial depolarization in L6 myoblasts treated with concentrations of each uncoupler at 1 and 10 μM, as measured by tetramethylrhodamine (TMRM) fluorescence. Neither FCCP nor BAM15 donates electrons to the Electron Transport Chain. Although some non-protonophoric uncouplers increase proton transport into the matrix via interaction with the mitochondrial inner membrane adenine nucleotide translocase (ANT), neither BAM15 nor FCCP requires the ANT to increase mitochondrial respiration.
storageStore at -20°C
References1) Kenwood et al. (2015), Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers; Bioorg. Med. Chem. Lett., 25 4858 2) Kenwood et al. (2013), Identification of a Novel Mitochondrial Uncoupler That Does Not Depolarize the Plasma Membrane; Mol. Metab., 3 114 3) Axelrod et al. (2020), BAM15-mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control; EMBO Mol. Med., Jun 10; e12088 4) Alexopoulos et al. (2020), Mitochondrial Uncoupler BAM15 Reverses Diet-Induced Obesity and Insulin Resistance in Mice; Nat. Commun., 11 2397 5) Tang et al. (2019), BAM15 Attenuates Transportation-Induced Apoptosis in iPS-differentiated Retinal Tissue; Stem Cell Res. Ther., 10 64
BAM15 Preparation Products And Raw materials
Tag:BAM15(210302-17-3) Related Product Information
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