CS-2890
中文名称 | CS-2890 |
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中文同义词 | 化合物BAM 15;N5,N6-双(2-氟苯基)-[1,2,5]恶二唑并[3,4-B]吡嗪-5,6-二胺;CS-2890 BAM15;BAM 15,线粒体质子解偶联剂 |
英文名称 | BAM15 |
英文同义词 | BAM15;N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;CS-2890;[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine, N5,N6-bis(2-fluorophenyl)-;BAM15 >=98% (HPLC);BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine);inhibit,BAM-15,Inhibitor,BAM 15,BAM15,Mitochondrial Metabolism |
CAS号 | 210302-17-3 |
分子式 | C16H10F2N6O |
分子量 | 340.29 |
EINECS号 | 201-118-7 |
相关类别 | 抑制剂 |
Mol文件 | 210302-17-3.mol |
结构式 |
CS-2890 性质
沸点 | 421.7±55.0 °C(Predicted) |
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密度 | 1.548±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 溶于DMSO(35mg/ml) |
酸度系数(pKa) | -2.40±0.50(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 1 个月。 |
Target | Value |
AMPK
() |
BAM 15 is able to increase O 2 consumption across a broad dosing range without increasing ROS. BAM 15 and FCCP are structurally unrelated and it is observed that low doses of BAM 15 from 100 nM to 1 μM increase cellular O 2 consumption rate (OCR) to a similar degree as FCCP, but higher concentrations from 1 μM to 50 μM reveal that BAM 15 is able to maintain uncoupled respiration at a high rate in a range of cell lines. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes. BAM 15 induces mitochondrial swelling, demonstrating that BAM 15 is a protonophore. BAM15-treated cells are more viable than FCCP-treated cells when administered across a broad dosing range up to 50 μM.
Compare to vehicle-treated mice, animals that receive BAM 15 are protected from kidney injury as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less depletion of brush border villi, less obstruction of proximal tubules, and less immune cell infiltration.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-110284 | BAM 15 | 1 mg | 340元 | |
2024/08/19 | HY-110284 | CS-2890 BAM 15 | 210302-17-3 | 5mg | 750元 |