| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Prodipine hydrochloride
CAS:31314-39-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Prodipine hydrochloride
CAS:31314-39-3
Purity:98% Package:1mg
|
Prodipine (hydrochloride) manufacturers
|
| | Prodipine (hydrochloride) Basic information |
| | Prodipine (hydrochloride) Chemical Properties |
| Melting point | 267° | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | Off-white to yellow |
| | Prodipine (hydrochloride) Usage And Synthesis |
| Biological Activity | Prodipine (hydrochloride) is a diphenylphosphonate derivative. Inhibits dipeptidyl peptidase IV (DPP IV) in purified rabbit and plasma with IC50 of 4.5 μM and 30 μM, respectively. | | in vitro | Prodipine (hydrochloride), a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC 50 values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively. | | in vivo | Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine (hydrochloride) or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remains unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery. | | target | IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV) |
| | Prodipine (hydrochloride) Preparation Products And Raw materials |
|