Prodipine (hydrochloride)
中文名称 | Prodipine (hydrochloride) |
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中文同义词 | 普罗地平盐酸盐;化合物 T13826 |
英文名称 | Prodipine (hydrochloride) |
英文同义词 | Prodipine (hydrochloride) |
CAS号 | 31314-39-3 |
分子式 | C20H26ClN |
分子量 | 315.89 |
EINECS号 | |
相关类别 | |
Mol文件 | 31314-39-3.mol |
结构式 | ![]() |
Prodipine (hydrochloride) 性质
熔点 | 267° |
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储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 米白色至黄色 |
IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV)
Prodipine, a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC 50 values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively.
Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remaines unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery.
安全信息
海关编码 | 2933399990 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101605 | Prodipine (hydrochloride) Prodipine hydrochloride | 31314-39-3 | 1 mg | 1000元 |
2024/04/30 | HY-101605 | Prodipine hydrochloride | 5 mg | 2500元 |