| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:DeMethylasterriquinone B1;2-[2-(1,1-DiMethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-Methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
CAS:78860-34-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:Demethylasterriquinone B1
CAS:78860-34-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | DEMETHYLASTERRIQUINONE B1 Basic information |
| Product Name: | DEMETHYLASTERRIQUINONE B1 | | Synonyms: | 2,5-DIHYDROXY-3-[7-(3-METHYL-BUT-2-ENYL)-1H-INDOL-3-YL]-6-[2-(1,1-DIMETHYL-ALLYL)-1H-INDOL-3-YL]-[1,4]BENZOQUINONE;2-[2-(1,1-DIMETHYL-2-PROPENYL)-1H-INDOL-3-YL]-3,6-DIHYDROXY-5-[7-(3-METHYL-2-BUTENYL)-1H-INDOL-3-YL]-2,5-CYCLOHEXADIENE-1,4-DIONE;2-[2-(1,1-DIMETHYLALLYL)-1H-INDOL-3-YL]-3,6-DIHYDROXY-5-[7-(3-METHYLBUT-2-ENYL)-1H-INDOL-3-YL][1,4]BENZOQUINONE;DAQ B1;DEMETHYLASTERRIQUINONE B1;DMAQ-B1;L-783,281;2-(2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl)-3,6-dihydroxy-5-(7-(3-methyl-2-butenyl)-1H-indol-3-yl)-2,5-cyclohexadiene- | | CAS: | 78860-34-1 | | MF: | C32H30N2O4 | | MW: | 506.59 | | EINECS: | | | Product Categories: | Protein Kinase | | Mol File: | 78860-34-1.mol |  |
| | DEMETHYLASTERRIQUINONE B1 Chemical Properties |
| Boiling point | 780.2±60.0 °C(Predicted) | | density | 1.335±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | pka | 2.82±0.50(Predicted) |
| | DEMETHYLASTERRIQUINONE B1 Usage And Synthesis |
| Description | Demethylasterriquinone B1 (DMAQ B1) is a natural insulin mimic that activates insulin receptor tyrosine kinase (IRTK; EC50 = 6 μM). It less potently activates IGF1R and EGFR (EC50s = 100 μM for both). DMAQ B1 induces glucose uptake in adipocytes and skeletal muscle cells without activating proliferation. DMAQ B1 binds GAPDH in vitro. | | Uses | Demethylasterriquinone B1 is a nonpeptidyl fungal metabolite that acted as an insulin mimetic in several biochemistry and cellular assays. | | Biological Activity | Selective insulin receptor (IR) activator/mimetic (EC 50 values are 3-6 μ M for IRTK and 100 μ M for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and downstream activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro , without enhancing vascular proliferation. Binds GAPDH. | | storage | Desiccate at -20°C |
| | DEMETHYLASTERRIQUINONE B1 Preparation Products And Raw materials |
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