2,4,6-三羟基苯乙酮
| 中文名称 | 2,4,6-三羟基苯乙酮 |
|---|---|
| 中文同义词 | 2,4,6-三羟基苯乙酮，水合;2',4',6'-三羟基苯乙酮一水合物;2',4',6'-三羟基苯乙酮水合物;2,4,6-三羟基苯乙酮;苯乙酮,2',4',6'-三羟基-;三羟基苯乙酮一水合物;乙酮,1-(2,4,6-三羟苯基)-;2',4',6'-三羟基苯乙酮一水合物(>98.0%(GC)) |
| 英文名称 | 2',4',6'-Trihydroxyacetophenone monohydrate |
| 英文同义词 | 2',4',6'-Trihydroxyacetophenone monohydrate;Phloroacetophenone monohydrate;2',4',6'-Trihydroxyacetophenone (monohydrate/anhydrous);2',4',6'-Trihydroxyacetophenone hydrate, 98+%;1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE;Acetophenone,2’,4’,6’-trihydroxy-;Acetophloroglucine;Acetylphloroglucinol |
| CAS号 | 480-66-0 |
| 分子式 | C8H8O4 |
| 分子量 | 168.15 |
| EINECS号 | 207-556-5 |
| 相关类别 | 微生物代谢物;通用试剂;医药中间体;有机砌块;中间体;其它有机金属化合物;醇类及衍生物;羰基化合物;小分子抑制剂;小分子抑制剂，天然产物;酮;活性分子;有机化工原料;其它酚类;医药原料;化工原料;合成材料中间体;中间体-有机中间体;Alcohols and Derivatives;Carbonyl Compounds;Aromatic Acetophenones & Derivatives (substituted);Analytical Chemistry;Mass Spectrometry;Matrix Materials (MALDI-TOF-MS);Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C7 to C8;Chemical Synthesis;Ketones;Organic Building Blocks;Inhibitors;化学试剂;对照品 |
| Mol文件 | 480-66-0.mol |
| 结构式 |  |
2,4,6-三羟基苯乙酮 性质
| 熔点 | 219-221 °C(lit.) |
|---|---|
| 沸点 | 257.07°C (rough estimate) |
| 密度 | 1.3037 (rough estimate) |
| 折射率 | 1.5090 (estimate) |
| 储存条件 | Store below +30°C. |
| 溶解度 | 可溶于DMSO（少量）、乙醇（少量）、甲醇（少量）、水（非常少量， |
| 酸度系数(pKa) | 7.76±0.23(Predicted) |
| 形态 | 粉末 |
| 颜色 | 浅黄色 |
| 水溶解性 | Soluble in water. |
| BRN | 1911197 |
| 稳定性 | 在建议的储存条件下稳定。 |
| LogP | 1.472 (est) |
| CAS 数据库 | 480-66-0(CAS DataBase Reference) |
| NIST化学物质信息 | Ethanone, 1-(2,4,6-trihydroxyphenyl)-(480-66-0) |
| EPA化学物质信息 | Ethanone, 1-(2,4,6-trihydroxyphenyl)- (480-66-0) |
Phloracetophenone (2,4,6-trihydroxyacetophenone) 是多叶姜黄 (Curcuma comosa Roxb) 中苯乙酮糖苷的糖苷配基部分，具有降低胆固醇作用，能够增强胆固醇 7α-羟化酶 (CYP7A1) 的活性；Phloracetophenone 通过 Mrp2 刺激胆汁分泌。
Cholesterol 7α-hydroxylase, Mrp2
Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level.
Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver.
Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis.
化学性质
微黄色结晶。熔点217-219℃。用途
本品用于有机合成、医药中间体和合成新型抗氧剂黄烷酮等。安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36-24/25 |
| WGK Germany | 3 |
| RTECS号 | AN0528000 |
| TSCA | Yes |
| 危险等级 | IRRITANT |
| 海关编码 | 29145000 |