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| | ST034307 Basic information |
| Product Name: | ST034307 | | Synonyms: | ST034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;ST034307;ST-034307;ST 034307;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;ST034307 >=98% (HPLC);Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase | | CAS: | 133406-29-8 | | MF: | C10H4Cl4O2 | | MW: | 297.95 | | EINECS: | | | Product Categories: | | | Mol File: | 133406-29-8.mol |  |
| | ST034307 Chemical Properties |
| Boiling point | 329.1±42.0 °C(Predicted) | | density | 1.674±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml) | | form | solid | | color | Yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | ST034307 Usage And Synthesis |
| Description | ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2 | | Uses | ST 034307 is a useful intermediate. | | storage | Store at -20°C | | References | 1) Brust?et al.?(2017),?Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal,?10?eaah5381
2) Jiang?et al,?(2018),?Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell?175?652
3) Watts (2018),?Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain;?Neuropsychopharmacology?43?215 |
| | ST034307 Preparation Products And Raw materials |
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