Mal-PEG4-Val-Cit-PAB-PNP manufacturers
- Mal-PEG4-Val-Cit-PAB-PNP
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- $0.00 / 100mg
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2024-03-29
- CAS:2112738-09-5
- Min. Order: 100mg
- Purity: >98.00%
- Supply Ability: 100mg
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| Mal-PEG4-Val-Cit-PAB-PNP Basic information |
Product Name: | Mal-PEG4-Val-Cit-PAB-PNP | Synonyms: | Mal-PEG4-Val-Cit-PAB-PNP;L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl (4-nitrophenyl) carbonate;4-((17S,20S)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate | CAS: | 2112738-09-5 | MF: | C40H53N7O15 | MW: | 871.89 | EINECS: | | Product Categories: | Linker;ADC LINKER | Mol File: | 2112738-09-5.mol | |
| Mal-PEG4-Val-Cit-PAB-PNP Chemical Properties |
solubility | Soluble in DMSO, DMF | form | Solid | color | Light yellow to yellow |
| Mal-PEG4-Val-Cit-PAB-PNP Usage And Synthesis |
Description | Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group. | Biological Activity | Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC). | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | target | |
| Mal-PEG4-Val-Cit-PAB-PNP Preparation Products And Raw materials |
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