1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione manufacturers
- Mal-PEG2-amine TFA salt
-
- $0.00 / 500mg
-
2024-03-27
- CAS:660843-23-2
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
|
| 1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione Basic information |
Product Name: | 1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione | Synonyms: | 1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione;O-(2-aminoethyl)-O'-(2-maleimidoethyl)ethylene glycol trifluoroacetate salt;Mal-PEG2-NH2 (TFA);1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione 2,2,2-trifluoroacetate;1-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-1H-pyrrole-2,5-dione Trifluoroacetate | CAS: | 660843-23-2 | MF: | C12H17F3N2O6 | MW: | 342.27 | EINECS: | | Product Categories: | | Mol File: | 660843-23-2.mol | ![1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione Structure](CAS/20180527/GIF/660843-23-2.gif) |
| 1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione Chemical Properties |
form | Oil | color | Off-white to light yellow |
| 1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione Usage And Synthesis |
Biological Activity | Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| 1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione Preparation Products And Raw materials |
|