Mal-PEG2-Val-Cit-amido-PAB-OH manufacturers
- Mal-PEG2-Val-Cit-PAB-OH
-
- $0.00 / 100mg
-
2024-03-29
- CAS:2055041-38-6
- Min. Order: 100mg
- Purity: >95.00%
- Supply Ability: 100mg
|
| Mal-PEG2-Val-Cit-amido-PAB-OH Basic information |
Product Name: | Mal-PEG2-Val-Cit-amido-PAB-OH | Synonyms: | Mal-PEG2-Val-Cit-amido-PAB-OH;Mal-PEG2-Val-Cit-PAB-OH;L-Ornithinamide, N-[3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | CAS: | 2055041-38-6 | MF: | C29H42N6O9 | MW: | 618.68 | EINECS: | | Product Categories: | ADC LINKER | Mol File: | 2055041-38-6.mol | |
| Mal-PEG2-Val-Cit-amido-PAB-OH Chemical Properties |
Boiling point | 948.4±65.0 °C(Predicted) | density | 1.294±0.06 g/cm3(Predicted) | solubility | Soluble in DMSO, DMF | pka | 13.41±0.70(Predicted) |
| Mal-PEG2-Val-Cit-amido-PAB-OH Usage And Synthesis |
Description | Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. PEG chain increases the water solubility of the compound. |
| Mal-PEG2-Val-Cit-amido-PAB-OH Preparation Products And Raw materials |
|