LP-211
| 中文名称 | LP-211 |
|---|---|
| 中文同义词 | 化合物LP-211 |
| 英文名称 | N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide |
| 英文同义词 | LP-211;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;LP-211; LP 211; LP211;1052147-86-0;LP21;LP-211 >=98% (HPLC);LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]- |
| CAS号 | 1052147-86-0 |
| 分子式 | C30H34N4O |
| 分子量 | 466.62 |
| EINECS号 | |
| 相关类别 | API |
| Mol文件 | 1052147-86-0.mol |
| 结构式 |  |
LP-211 性质
| 沸点 | 714.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.17±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:100.0(最大浓度 mg/mL);214.3(最大浓度 mM) 乙醇:50.0(最大浓度 mg/mL);107.15(最大浓度 mM) |
| 酸度系数(pKa) | 15.39±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 透明白色至浅棕色 |
|
5-HT 7 Receptor 0.58 nM (Ki) |
5-HT 1A Receptor 188 nM (Ki) |
D 2 Receptor 142 nM (Ki) |
LP-211 is a selective 5-HT 7 receptor agonist, with a K i of 0.58 nM, 324- and 245-fold selectivity over 5-HT 1A receptor (K i , 188 nM) and D 2 receptor (K i , 142 nM). LP-211 shows agonist properties with an EC 50 of 0.6 μM.
LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean C max of 0.76 ± 0.32 μg/mL at 30 min. LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-111455 | LP-211 LP-211 | 1052147-86-0 | 5mg | 800元 |
| 2024/08/19 | HY-111455 | LP-211 LP-211 | 1052147-86-0 | 10mM * 1mLin DMSO | 880元 |