- LP-211
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- $39.00 / 2mg
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2024-11-19
- CAS:1052147-86-0
- Min. Order:
- Purity: 98.65%
- Supply Ability: 10g
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| | N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Basic information |
| Product Name: | N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide | | Synonyms: | LP-211;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;LP-211; LP 211; LP211;1052147-86-0;LP21;LP-211 >=98% (HPLC);LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP-211, 10 mM in DMSO | | CAS: | 1052147-86-0 | | MF: | C30H34N4O | | MW: | 466.62 | | EINECS: | | | Product Categories: | API | | Mol File: | 1052147-86-0.mol |  |
| | N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemical Properties |
| Boiling point | 714.8±60.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM) | | pka | 15.39±0.46(Predicted) | | form | solid | | color | clear white to light brown |
| | N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Usage And Synthesis |
| Uses | LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity. | | Biochem/physiol Actions | LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome. |
| | N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Preparation Products And Raw materials |
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