Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:R-(+)-Warfarin CAS:5543-58-8 Package:50Mg,5Mg
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Company Name: |
Chemsky(shanghai)International Co.,Ltd.
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Tel: |
021-50135380 |
Email: |
shchemsky@sina.com |
Products Intro: |
Product Name:4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one CAS:5543-58-8 Purity:98%+
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| (R)-(+)-WARFARIN Basic information |
Product Name: | (R)-(+)-WARFARIN | Synonyms: | 4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one;(R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone;(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin;r-(+)-3-acetonybenzyl)-4-hydroxycoumarin;2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]- (9CI);Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, R-(+)- (8CI);Dextrowarfarin | CAS: | 5543-58-8 | MF: | C19H16O4 | MW: | 308.33 | EINECS: | 226-908-9 | Product Categories: | Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | Mol File: | 5543-58-8.mol | ![(R)-(+)-WARFARIN Structure](CAS/GIF/5543-58-8.gif) |
| (R)-(+)-WARFARIN Chemical Properties |
Melting point | ≥170 °C | Boiling point | 515.2±50.0 °C(Predicted) | density | 1.307±0.06 g/cm3(Predicted) | storage temp. | 2-8°C | solubility | DMF: soluble | form | A crystalline solid | pka | 4.50±1.00(Predicted) | color | white to pale yellow |
| (R)-(+)-WARFARIN Usage And Synthesis |
Chemical Properties | White Solid | Uses | The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant. | Uses | (R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles | Definition | ChEBI: (R)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (R)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (R)-warfarin(1-). It is an enantiomer of a (S)-warfarin. | General Description | The chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers. | Biochem/physiol Actions | Warfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures. |
| (R)-(+)-WARFARIN Preparation Products And Raw materials |
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