2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
| 中文名称 | 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE |
|---|---|
| 中文同义词 | 盐酸瑞马酰胺;化合物 T23231;2-氨基-N-(1-甲基-1,2-二苯乙基)乙酰胺盐酸盐 |
| 英文名称 | 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE |
| 英文同义词 | REMACEMIDE HYDROCHLORIDE;2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE;RemacemideHCl;2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride;2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid;2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-;fpl12924aa;pr934-423a |
| CAS号 | 111686-79-4 |
| 分子式 | C17H21ClN2O |
| 分子量 | 304.82 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 111686-79-4.mol |
| 结构式 |  |
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE 性质
| 熔点 | 253-254° |
|---|---|
| 储存条件 | room temp |
| 溶解度 | H2O：>10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble to 100 mM in water |
Remacemide hydrochloride (FPL 12924AA) 是一种钠离子通道的中等强度抑制剂，是 N-methyl-D-aspartate (NMDA) 受体 的弱无竞争力拮抗剂，对于 MK-801 结合的 IC50 值为 68 μM，对于 NMDA 电流的 IC50 值为 76 μM。Remacemide hydrochloride 是一种抗惊厥剂。
IC50: 68-76 μM (NMDA receptor)
IC50:160.6 μM(sodium channel)
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na + channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC 50 value of 160.6 μM.
Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats.
| Animal Model: | Female Sprague–Dawley rats ( 190-210 g ) |
| Dosage: | 100 mg/kg and 150 mg/kg |
| Administration: | Orogastric gavage; once a day; 7 days |
| Result: | Increased the number of sessions required to complete audio/visual discrimination (AVD) training. |
安全信息
| 危险品标志 | Xn,N |
|---|---|
| 危险类别码 | 22-41-50/53 |
| 安全说明 | 26-39-45-60-61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS号 | AB4349500 |
| 毒性 | LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer) |