呋喃茶碱
中文名称 | 呋喃茶碱 |
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中文同义词 | 呋喃茶碱;呋喃菲林;呋拉茶碱;3-(呋喃-2-基甲基)-1,8-二甲基-1H-嘌呤-2,6(3H,7H)-二酮 |
英文名称 | 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE |
英文同义词 | FURAFYLLINE;3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE;Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione;FURAFYLLINE INHIBITOR OF CYTOCHRO;1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-;3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione;Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline;Furatheophylline |
CAS号 | 80288-49-9 |
分子式 | C12H12N4O3 |
分子量 | 260.25 |
EINECS号 | 200-158-5 |
相关类别 | 试剂 |
Mol文件 | 80288-49-9.mol |
结构式 | ![]() |
呋喃茶碱 性质
熔点 | >162°C (dec.) |
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沸点 | 543.6±60.0 °C(Predicted) |
密度 | 1.443±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C(protect from light) |
溶解度 | 乙醇:0.33 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 8.62±0.70(Predicted) |
颜色 | 白色 |
InChIKey | KGQZGCIVHYLPBH-UHFFFAOYSA-N |
IC50: 0.07 μM (human cytochrome P450IA2)
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-107204 | 呋喃茶碱 Furafylline | 80288-49-9 | 1mg | 1500元 |
2024/04/30 | HY-107204 | 呋喃茶碱 Furafylline | 80288-49-9 | 5mg | 3750元 |