10,12-二十三联炔酸
中文名称 | 10,12-二十三联炔酸 |
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中文同义词 | 10,12-二十三联炔酸;10,12-二十三碳二炔酸;10,12-二十三碳二炔酸,96% |
英文名称 | 10,12-TRICOSADIYNOIC ACID |
英文同义词 | 10,12-TRICOSADIYNOIC ACID;TIMTEC-BB SBB009036;tricosa-10,12-diynoic acid;10,12-Tricosadiynoic acid >=98.0% (GC);10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%;10,12-Tricosadiynoicaci;10,12-Tricosadiynoic acid,ROS,mono- acylglycerol acyltransferase,10,12Tricosadiynoic acid,fatty,Diacylglycerol acyltransferase,SIRT1-AMPK,Diglyceride acyltransferase,metabolic,mitochondrial,oxidation,insulin,10,12 Tricosadiynoic acid,inhibit,triglyceride,Inhibitor,Acyltransferase,acyl-CoA:cholesterol acyltransferase,acid |
CAS号 | 66990-30-5 |
分子式 | C23H38O2 |
分子量 | 346.55 |
EINECS号 | |
相关类别 | 自组装和接触印刷;Acetylenes;Acetylenic Carboxylic Acids & Their Derivatives;Diacetylene Monocarboxylic Acids;Functional Materials;LB Films |
Mol文件 | 66990-30-5.mol |
结构式 | ![]() |
10,12-二十三联炔酸 性质
熔点 | 56-60 °C |
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储存条件 | Refrigerator |
溶解度 | 二甲基亚砜:100mg/mL(288.56mM) |
形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Insoluble in water. |
敏感性 | Light Sensitive |
BRN | 1880414 |
CAS 数据库 | 66990-30-5(CAS DataBase Reference) |
Acyl-CoA oxidase-1 (ACOX1).
10,12-Tricosadiynoic acid-CoA rapidly inhibits ACOX1 activity in a time- and concentration-dependent manner. The activity of ACOX1 decreases by nearly 95% after 5 min of incubation with 10 eq of 10,12-Tricosadiynoic acid-CoA. ACOX1 activity is inhibited only if free 10,12-Tricosadiynoic Acid is activated as the CoA thioester, the substrate form. Inhibition of ACOX1 by 10,12-Tricosadiynoic acid-CoA is irreversible. And the kinetics parameters KI and kinact are calculated to be 680 nm and 3.18 min
−1
, respectively.
10,12-Tricosadiynoic acid is the precursor of 10,12-Tricosadiynoic acid-CoA and is transformed into 10,12-Tricosadiynoic acid-CoA by peroxisomal very long chain acyl-CoA synthetase (VLACS) after entering into cells, and it inhibits ACOX1 in vivo.
10,12-Tricosadiynoic acid (500 nM) inhibits acyl-CoA oxidase-1 (ACOX1) activity. 10,12-Tricosadiynoic acid treatment abrogates the protective effect by Sirt5 siRNA.
10,12-Tricosadiynoic acid (100 μg/kg; oral gavage; daily; for 8 weeks; male Wistar rats) treatment increases hepatic mitochondrial fatty acid oxidation (FAO) via activation of the SIRT1-AMPK (adenosine 5′-monophosphate-activated protein kinase) pathway and proliferator activator receptor α and reduces hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreases hepatic lipid and ROS contents, reduces body weight gain, and decreases serum triglyceride and insulin levels.
10,12-Tricosadiynoic acid (0 mg/kg, 37.5 mg/kg, 75 mg/kg, and 150 mg/kg diet) treatment does not affect weight gain, but significantly decreases peroxisomal β-oxidation in the liver, and increased body fat accumulation in Nile tilapia. The fish with impaired peroxisomal β-oxidation exhibited higher contents of serum lipid and peroxidation products, and alanine aminotransferase activity, and significantly lowered hepatic activities of superoxide dismutase and catalase.
Animal Model: | Male Wistar rats (210-230 g) fed with high fat diet |
Dosage: | 100 μg/kg |
Administration: | Oral gavage; daily; for 8 weeks |
Result: | Reduced hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreased hepatic lipid and ROS contents, reduced body weight gain, and decreased serum triglyceride and insulin levels. |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | L10231 | 10,12-二十三碳二炔酸, 96% 10,12-Tricosadiynoic acid, 96% | 66990-30-5 | 1g | 733元 |
2024/08/19 | L10231 | 10,12-二十三碳二炔酸, 96% 10,12-Tricosadiynoic acid, 96% | 66990-30-5 | 5g | 2589元 |