9-CIS-RETINOIC ACID

9-CIS-RETINOIC ACID Suppliers list
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86 13288715578 +8613288715578
Email: sales@hbmojin.com
Products Intro: Product Name:9-cis-Retinoic Acid
CAS:5300-03-8
Purity:99% Package:25KG
Company Name: Hebei Weibang Biotechnology Co., Ltd
Tel: +8617732866630
Email: bess@weibangbio.com
Products Intro: Product Name:9-cis-Retinoic Acid
CAS:5300-03-8
Purity:99% Package:1KG;30.00;USD|10KG;20.00;USD|100KG;10.00;USD
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
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Products Intro: Product Name:TIANFU CHEM---9-CIS-RETINOIC ACID
CAS:5300-03-8
Purity:99% Package:25KG;5KG;1KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714
Email: FandaChem@Gmail.com
Products Intro: Product Name:9-cis retinoic acid (Alitretinoin)
CAS:5300-03-8
Purity:As coa Package:As request
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Tretinoin EP Impurity D
CAS:5300-03-8
Purity:0.99 Package:10mg;25mg;50mg;100mg

9-CIS-RETINOIC ACID manufacturers

  • 9-cis-Retinoic Acid
  • 9-cis-Retinoic Acid pictures
  • $78.00 / 2mg
  • 2024-11-06
  • CAS:5300-03-8
  • Min. Order:
  • Purity: ≥98%
  • Supply Ability: 10g
  • 9-cis-Retinoic Acid
  • 9-cis-Retinoic Acid pictures
  • $30.00 / 1KG
  • 2024-11-04
  • CAS:5300-03-8
  • Min. Order: 50KG
  • Purity: 99%
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  • 9-cis-Retinoic Acid
  • 9-cis-Retinoic Acid pictures
  • $0.00 / 25KG
  • 2023-10-16
  • CAS:5300-03-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50000KG/month
9-CIS-RETINOIC ACID Basic information
Product Name:9-CIS-RETINOIC ACID
Synonyms:RETINOIC ACID, 9-CIS-;RARECHEM AL BE 0738;(2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-ENYL)NONA-2,4,6,8-TETRAENOIC ACID;9-CIS-RETINOIC ACID;9-CIS-TRETINOIN;9-cis-tretinoi;3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-t;ALIRETINOIN
CAS:5300-03-8
MF:C20H28O2
MW:300.44
EINECS:1533716-785-6
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids
Mol File:5300-03-8.mol
9-CIS-RETINOIC ACID Structure
9-CIS-RETINOIC ACID Chemical Properties
Melting point 189-191°C
Boiling point 462.8±14.0 °C(Predicted)
density 1.011±0.06 g/cm3(Predicted)
RTECS VH6450000
storage temp. -20°C
solubility Acetonitrile (Very Slightly), Chloroform (Slightly), DMSO (Slightly), Ethanol (
pka4.73±0.33(Predicted)
form Light yellow to orange crystalline powder.
color Pale Yellow to Yellow
Water Solubility Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
Sensitive Moisture & Light Sensitive
Stability:Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
CAS DataBase Reference5300-03-8(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 61-36/37/38
Safety Statements 53-26-36/37/39-45
WGK Germany 3
HS Code 29162090
Hazardous Substances Data5300-03-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
9-CIS-RETINOIC ACID Usage And Synthesis
DescriptionAlitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.
Chemical PropertiesPale Yellow Solid
OriginatorLigand (US)
Uses9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.
UsesAn endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.
DefinitionChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
IndicationsAlitretinoin (Panretin) is a naturally occurring endogenous retinoid that binds to and activates all known retinoid receptors (both RARs and RXRs). It is approved for the topical treatment of cutaneous lesions of Kaposi’s sarcoma. Most patients have local irritation while using alitretinoin gel; however, the irritation rarely necessitates discontinuation of therapy.
Brand namePanretin (Ligand).
Biochem/physiol ActionsLigand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.
9-CIS-RETINOIC ACID Preparation Products And Raw materials
Tag:9-CIS-RETINOIC ACID(5300-03-8) Related Product Information
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