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| (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid Basic information |
Product Name: | (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid | Synonyms: | (4-cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid(WX192149);Boronic acid, B-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-;(4-cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid;B-(4-Cyclopropyl-6-methoxy-pyrimidin-5-yl)boronic acid;4-Cyclopropyl-6-methoxypyrimidine-5-boronic Acid | CAS: | 1798304-51-4 | MF: | C8H11BN2O3 | MW: | 194 | EINECS: | | Product Categories: | | Mol File: | 1798304-51-4.mol | ![(4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid Structure](CAS/20200611/GIF/1798304-51-4.gif) |
| (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid Chemical Properties |
Boiling point | 402.1±55.0 °C(Predicted) | density | 1.32±0.1 g/cm3(Predicted) | pka | 2.49±0.58(Predicted) | InChI | InChI=1S/C8H11BN2O3/c1-14-8-6(9(12)13)7(5-2-3-5)10-4-11-8/h4-5,12-13H,2-3H2,1H3 | InChIKey | BYXHEUWWJYYRNH-UHFFFAOYSA-N | SMILES | B(C1=C(OC)N=CN=C1C1CC1)(O)O |
| (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid Usage And Synthesis |
Synthesis | To a stirred solution of 5-bromo-4-cyclopropyl-6-methoxy-pyrimidine in toluene and tetrahydrofuran was added triisopropyl borate at room temperature under nitrogen atmosphere. The mixture was cooled down to -70 °C. To the above mixture was slowly added n-butyl lithium dropwise at -70 °C. The resulting mixture was stirred for additional 15 min at -70 °C. The reaction was quenched with 1N HCl at -70 °C. The mixture was purified by RP-Flash, the collected fractions were combined and concentrated under reduced pressure to afford (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid (3.5 g, 18.04 mmol, 94% yield) as a white solid.
![(4-cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid(WX192149) (4-cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid(WX192149)](/NewsImg/2023-11-07/6383496156263140287353242.jpg) |
| (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid Preparation Products And Raw materials |
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