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Hemin

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Products Intro: Product Name:Hemin
CAS:16009-13-5
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Products Intro: Product Name:Chlorohemin
CAS:16009-13-5
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CAS:16009-13-5
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Hemin manufacturers

  • Hemin
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  • $30.00 / 500mg
  • 2024-11-12
  • CAS:16009-13-5
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  • Hemin
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  • 2024-11-12
  • CAS:16009-13-5
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Hemin Basic information
Product Name:Hemin
Synonyms:HEMATIN HYDROCHLORIDE;HEMIN;HEMIN, BOVINE;HEMIN CHLORIDE BOVINE;HEMIN CHLORIDE PORCINE;HEMIN (EX PORCINE, BOVINE, EQUINE);HAEMIN;FERRIPROTOPORPHRIN IX CHLORIDE
CAS:16009-13-5
MF:C34H31ClFeN4O4-
MW:650.94
EINECS:240-140-1
Product Categories:organic amine;Organometallics;Biochemistry;Classes of Metal Compounds;Fe (Iron) Compounds;Transition Metal Compounds;Natural Porphyrins and Derivitives;Porphyrins;16009-13-5
Mol File:16009-13-5.mol
Hemin Structure
Hemin Chemical Properties
Melting point 300 °C
storage temp. 2-8°C
solubility 1.4 M NaOH: soluble25mg/mL
form crystal
color black
Water Solubility practically insoluble
Merck 14,4644
BRN 5229914
Exposure limitsACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3
Stability:Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKeyBTIJJDXEELBZFS-HXFTUNQESA-K
SMILES[Cl-][Fe+3]123[N-]4C5C(C)=C(C=C)C4=CC4C(C)=C(C=C)C(=CC6=C(C)C(CCC(=O)[O-])=C(C=C7C(CCC(=O)[O-])=C(C)C(C=5)=N17)[N-]26)N3=4.[H+]
EPA Substance Registry SystemFerrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-5-13)- (16009-13-5)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-22-36-26
WGK Germany 3
RTECS LJ8080000
8
TSCA Yes
HS Code 29349990
MSDS Information
ProviderLanguage
Chloroprotoporphyrin IX iron(III) English
SigmaAldrich English
ACROS English
ALFA English
Hemin Usage And Synthesis
DescriptionHemin is a metalloporphyrin compound with a relatively simple structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is an in vitro group substitute of natural heme and its chemical properties are similar to that of heme. Heme, an essential small molecule in living organisms, can be found abundantly in various organisms including animals, plants, microorganisms, and algae.
Chemical PropertiesHemin is a Dark purple crystalline powder or elongated needle-shaped crystal. It does not dissolve in water, but it can dissolve in acidic acetone and alkaline water. The molecular formula is C34H32ClFe(III)N4O4, and the molecular weight is 651.96. Hemin is mainly used as raw material for anti-anemia and anti-cancer drugs.
ApplicationHemin is used for the following applications:
To study bacterial strains and growth conditions
Used in short-term colony assays (the culture medium consists of hemin along with other components)
Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.
UsesHemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture.
General DescriptionHeme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin.
Biochem/physiol ActionsHemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.
Purification MethodsHemin is purified by recrystallisation from AcOH. Also, hemin (5g) is shaken in pyridine (25mL) till it dissolves, then CHCl3 (40mL) is added, the container is stoppered and shaken for 5minutes (releasing the stopper occasionally). The solution is filtered under slight suction, and the flask and filter are washed with a little CHCl3 (15mL). During this period, AcOH (300mL) is heated to boiling, and saturated aqueous NaCl (5mL) and conc HCl (4mL) are added. The CHCl3 filtrate is poured in a steady stream, with stirring, into the hot AcOH mixture and set aside for 12hours. The crystals are filtered off, washed with 50% aqueous AcOH (50mL), H2O (100mL), EtOH (25mL), Et2O and dried in air. [Fischer Org Synth Coll Vol III 442 1955, Beilstein 26 III/IV 3048.]
Hemin Preparation Products And Raw materials
Raw materialsDiethylamine-->Dichloroacetic acid-->Strontium chloride-->Cellulose-DEAE,DE 32
Preparation ProductsHematoprophyrin-->HEMATOPORPHYRIN
Tag:Hemin(16009-13-5) Related Product Information
Iron saccharate PHYTOHEMAGGLUTININ PHA-M Hematin Bethanechol Allylacetic acid 2,3,4,5-TETRAMETHYLPYRROLE Allylamine hydrochloride 4-HEXENOIC ACID 6-Heptenoic acid 3-BUTEN-1-AMINE 2,5-Dimethyl-1H-pyrrole 2,4-Dimethylpyrrole PROTOPORPHYRIN IX DIMETHYL ESTER FROM*OX HEMIN BOVINE HEMIN Hemin (Ferriprotoporphyrin IX chloride), min. 95%,HEMIN (FERRIPROTOPORPHYRIN IX CHLORIDE), MIN. 95,Hemin (Ferriprotoporphyrin IX chloride) PORPHINE Protoporphyrin IX Difluorochloromethane