3,4-二羟基苄胺·氢溴酸
中文名称 | 3,4-二羟基苄胺·氢溴酸 |
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中文同义词 | 3,4-二羟基苯甲胺氢溴酸盐,98%;3,4-二羟基苯甲胺氢溴酸盐;3,4-二羟基苄胺;3,4-二羟基苄胺氢溴酸盐;4-(氨甲基)儿茶酚 氢溴酸盐;DHBA 氢溴酸盐;3,4-二羟基苄胺氢溴酸盐(DHBA氢溴酸盐、4-(氨甲基)儿茶酚氢溴酸盐、3,4-二羟基苄胺.氢溴酸、3,4-二羟基苯甲胺氢溴酸盐);3,4-二羟基苄胺·氢溴酸 |
英文名称 | 3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE |
英文同义词 | 4-(AMINOMETHYL)CATECHOL HYDROBROMIDE;3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE;DHBA HYDROBROMIDE;4-(aminomethyl)pyrocatechol hydrobromide;3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE, 9 8%;4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide;3,4-Dihydroxybenzylamine·hydrogen bromide;4-(Aminomethyl)pyrocatechol·hydrobrominate |
CAS号 | 16290-26-9 |
分子式 | C7H10BrNO2 |
分子量 | 220.06 |
EINECS号 | 240-382-8 |
相关类别 | 中药对照品;Anilines, Aromatic Amines and Nitro Compounds |
Mol文件 | 16290-26-9.mol |
结构式 |
3,4-二羟基苄胺·氢溴酸 性质
熔点 | 184-186 °C(lit.) |
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储存条件 | Inert atmosphere,Room Temperature |
溶解度 | 可溶于DMSO(轻微)、甲醇(非常轻微) |
形态 | 结晶粉末 |
颜色 | 浅米色低熔点 |
敏感性 | Hygroscopic |
BRN | 4002646 |
CAS 数据库 | 16290-26-9(CAS DataBase Reference) |
3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines with an IC 50 of 100 μM, while the SK-MELB cell line exhibits an IC 50 of 122 μM. The IC 50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. It exhibits IC 50 values of 10, 25, 67, and 184 μM for S91A,S91B, L1210, and SCC-25 cells, respectively.3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC 50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line.
Cell Viability Assay
Cell Line: | Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines |
Concentration: | 1 μM-10 mM |
Incubation Time: | 48 hours |
Result: | Inhibited melanoma cell Lines growth. |
3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 1000 mg/kg; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose. 3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 200-800 mg/kg; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days for 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively.
Animal Model: | C57BL/6 mice with B6D2F1 cells |
Dosage: | 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg |
Administration: | Intraperitoneal injection |
Result: | Exhibited increased life-span of 44%,46%, 70% and 50% for 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively. |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | 22857 | 3,4-二羟基苯甲胺 氢溴酸盐 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 250mg | 625元 |
2024/08/19 | 22857 | 3,4-二羟基苯甲胺 氢溴酸盐 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 1g | 1568元 |