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Amatek Scientific Co. Ltd.
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Product Name:2-(3-Trifluoromethylphenyl)propanoic acid
CAS:68718-08-1
Purity:97% HPLC Package:1g;5g;25g;100g
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Aikon International Limited
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025-58859352 18068836627 |
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| Products Intro: |
Product Name:2-(3-(Trifluoromethyl)phenyl)propanoic acid
CAS:68718-08-1
Purity:95+% Package:1g;5g;10g
|
| Company Name: |
Sichuan Boyou Biotechnology Co., Ltd
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028-65791793 18140026355 |
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| Products Intro: |
Product Name:2-(3-(trifluoromethyl)phenyl)propanoic acid
CAS:68718-08-1
Purity:95 Package:10G;100G;1KG;5KG
|
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| | 2-(3-trifluoromethylphenyl)propionic acid Basic information |
| Product Name: | 2-(3-trifluoromethylphenyl)propionic acid | | Synonyms: | Benzeneacetic acid, α-methyl-3-(trifluoromethyl)-;2-(3-Trifluoromethylphenyl)propanoic acid;α-Methyl-3-(trifluoromethyl)-benzeneacetic Acid;2-(3-trifluoromethylphenyl)propionic acid | | CAS: | 68718-08-1 | | MF: | C10H9F3O2 | | MW: | 218.17 | | EINECS: | | | Product Categories: | | | Mol File: | 68718-08-1.mol |  |
| | 2-(3-trifluoromethylphenyl)propionic acid Chemical Properties |
| Boiling point | 249.6±35.0 °C(Predicted) | | density | 1.301±0.06 g/cm3(Predicted) | | pka | 4.20±0.10(Predicted) |
| | 2-(3-trifluoromethylphenyl)propionic acid Usage And Synthesis |
| Synthesis |
A solution of 3-(trifluoromethyl)phenylacetic acid (ALDRICH, 300 mg, 1 .470 mmol) in THF (2 mL) was added dropwise to a solution of lithium diisopropylamide, 2M solution in heptane/THF/ethylbenzene (ALDRICH, 2.94 mL, 5.88 mmol) in THF (5 mL) at -78 °C. After 1 h at -78 °C, methyl iodide (ALDRICH, 0.735 mL, 1 1.76 mmol) was added, and the solution was stirred for 1 hour. The mixture was hydrolyzed with 2N HCI until acidic pH was reached, extracted with DCM, dried over MgS04, filtered, and dried under vacuum to produce a crude. It was purified by flash column chromatography using hexane/EtOAc 85/15 to 0/100 to give 2-(3-trifluoromethylphenyl)propionic acid (304 mg, 1.39 mmol, 95% yield).
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| | 2-(3-trifluoromethylphenyl)propionic acid Preparation Products And Raw materials |
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