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JNJ-38877605

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
CAS:943540-74-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:JNJ-38877618；OMO-1
CAS:943540-74-7
Purity:98.00% Package:10 mg；100 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:OMO-1
CAS:943540-74-7
Purity:99% Package:5KG;1KG Remarks:OMO-1
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:JNJ-38877618
CAS:943540-74-7
Purity:98% Package:5mg Remarks:V4506
Company Name: Chemtour Biotech Co., Ltd
Tel: +8617327281506
Email: market@chemtour.com
Products Intro: Product Name:JNJ-38877618
CAS:943540-74-7
Purity:99% Package:5KG;1KG
JNJ-38877605 Basic information
Product Name:JNJ-38877605
Synonyms:JNJ-38877618;JNJ-38877618 (OMO1;OMO-1);6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline;Quinoline, 6-[difluoro[6-(4-pyridinyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-;6-[Difluoro[6-(4-pyridinyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline;JNJ-38877618,Inhibitor,c-Met/HGFR,JNJ 38877618,JNJ38877618,inhibit;Venadaparib Impurity 21
CAS:943540-74-7
MF:C20H12F2N6
MW:374.35
EINECS:
Product Categories:
Mol File:943540-74-7.mol
JNJ-38877605 Structure
JNJ-38877605 Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 5 mg/mL (13.36 mM)
form Solid
color White to off-white
Safety Information
MSDS Information
JNJ-38877605 Usage And Synthesis
Biological ActivityJNJ-38877618 (OMO-1) is a potent, highly selective, and orally bioavailable Met (c-Met) kinase inhibitor with a Kd of 1.4 nM. Its IC50 values for wild-type Met (c-Met) and mutant Met (c-Met) (M1268T) were 2 nM and 3 nM, respectively.
in vivo

In vivo, JNJ-38877618(OMO-1) completely inhibited tumor growth in 3 tumor models: SNU5 MET amp gastric cancer model, U87-MG HGF autocrine glioblastoma model, and exon 14 skipping deletion mutation Hs746T gastric cancer model of MET gene. Administration of OMO-1 in combination with other drugs is well tolerated and can improve and enhance the effect of EGFR-targeted therapy. Although single-agent OMO-1 has no effect on NSCLC HCC827 EGFR, its combination with erlotinib can delay tumor recurrence.

target< /table>
TargetValue
Met
(Cell-free assay)		 2 nM
MET (M1268T)
(Cell-free assay)		 3 nM
JNJ-38877605 Preparation Products And Raw materials
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