牛磺-Α-鼠胆酸
中文名称 | 牛磺-Α-鼠胆酸 |
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中文同义词 | 牛磺-Α-鼠胆酸;牛磺-贝塔-鼠胆酸钠盐;化合物 TAURO-Ω-MURICHOLIC ACID SODIUM;牛磺-Β-鼠胆酸钠盐;牛磺酸Β-鼠胆酸钠盐;牛磺-B鼠胆酸钠盐 |
英文名称 | Tauro--muricholic Acid (sodium salt) |
英文同义词 | Tauro-β-muricholic acid sodium;T-βMCA sodium;Tauro-β-muricholic Acid sodium salt;Tauro-β-muricholic acid sodium;T-βMCA sodium;2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt |
CAS号 | 145022-92-0 |
分子式 | C26H46NNaO7S |
分子量 | 539.7 |
EINECS号 | |
相关类别 | |
Mol文件 | 145022-92-0.mol |
结构式 | ![]() |
牛磺-Α-鼠胆酸 性质
熔点 | 120-125oC |
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储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
溶解度 | DMSO(少许)、甲醇(少许)、水(少许) |
形态 | 固体 |
颜色 | 白色至浅棕色 |
稳定性 | 吸湿性 |
IC50: 40 μM (FXR)
T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC
50
~10 μM).
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells.
T-βMCA sodium induces proliferation and DNA damage in Lgr5
+
cells.
T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression.
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17.
Animal Model: | APCmin/+ mice |
Dosage: | 400 mg/kg |
Administration: | Oral gavage; twice a week; for 6 weeks |
Result: | Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-135103 | 牛磺-Α-鼠胆酸 Tauro-β-muricholic acid sodium | 145022-92-0 | 1mg | 1800元 |