261766-73-8
| 中文名称 | 261766-73-8 |
|---|---|
| 中文同义词 | 化合物 T10169;化合物5-HT4 ANTAGONIST 1 |
| 英文名称 | 5-HT4 antagonist 1 |
| 英文同义词 | 5-HT4 antagonist 1;1,4-Benzodioxin-5-carboxamide, 2,3-dihydro-N-[[1-[3-[(4-methyl-1-piperazinyl)sulfonyl]propyl]-4-piperidinyl]methyl]-;inhibit,5-HT4 antagonist 1,5-hydroxytryptamine Receptor,Serotonin Receptor,5-HT Receptor,5 HT4 antagonist 1,5-HT-4 antagonist 1,Inhibitor,5HT4 antagonist 1 |
| CAS号 | 261766-73-8 |
| 分子式 | C23H36N4O5S |
| 分子量 | 480.62 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 261766-73-8.mol |
| 结构式 |  |
261766-73-8 性质
| 密度 | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.39±0.20(Predicted) |
5-HT4 antagonist 1 是一个 5-HT4 受体拮抗剂， 其 pKi 值为 9.6。
|
5-HT 4 Receptor 9.6 (pKi) |
5-HT4 antagonist 1 (compound 6b) is a 5-HT 4 receptor antagonist with a pK i of 9.6.
5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t 1/2 in other species, including the mouse (t 1/2 7 h), rat (t 1/2 12 h) and mini-pig (t 1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t 1/2 of >100 h.