Terlipressin Diacetate Salt
| 中文名称 | Terlipressin Diacetate Salt |
|---|---|
| 中文同义词 | 化合物TERLIPRESSIN ACETATE;双乙酸特利加压素;双醋酸特利加压素;特利加压素二乙酸盐 |
| 英文名称 | Terlipressin Diacetate Salt |
| 英文同义词 | Terlipressin Diacetate |
| CAS号 | 1884420-36-3 |
| 分子式 | C54H78N16O17S2 |
| 分子量 | 1287.43 |
| EINECS号 | |
| 相关类别 | 特利加压素 |
| Mol文件 | 1884420-36-3.mol |
| 结构式 |  |
Terlipressin Diacetate Salt 性质
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色 |
Terlipressin acetate 是一种具有血管活性的加压素类似物，也是一种高度选择性的加压素 V1 受体激动剂，可减少内脏血流量和门脉压力并控制急性静脉曲张破裂出血。Terlipressin acetate 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。
Vasopressin V1 receptor
Terlipressin (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells.
Terlipressin inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway.
Cell Proliferation Assay
| Cell Line: | IEC-6 cells induced by oxygen and glucose deprivation/re-oxygenation (OGD/R) |
| Concentration: | 25 nM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Significantly increased the proliferation of IEC-6 cells. |
Using a mouse nonlethal hepatic ischemia-reperfusion (IR) model, Terlipressin administration significantly ameliorates IR-induced liver apoptosis, necrosis and inflammation.