1346133-11-6
中文名称 | 1346133-11-6 |
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中文同义词 | 化合物 T11909;(S)-3-氟-4-(4-((2-(3-氟苯基)吡咯烷-1-基)甲基)苯氧基)苯甲酰胺;化合物LY2444296 |
英文名称 | (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide |
英文同义词 | (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide;LY2444296;FP3FBZ;Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]- |
CAS号 | 1346133-11-6 |
分子式 | C24H22F2N2O2 |
分子量 | 408.44 |
EINECS号 | |
相关类别 | |
Mol文件 | 1346133-11-6.mol |
结构式 |
1346133-11-6 性质
沸点 | 491.6±45.0 °C(Predicted) |
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密度 | 1.276±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 乙醇:27.5mg/mL(67.33mM);甲醇:5 mg/mL (12.24 mM) |
酸度系数(pKa) | 15.61±0.50(Predicted) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
Ki: ~1 nM (KOPR)
LY2444296 displays anti-anxiety like effects in the EPM test.
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-naïve rats.
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-naïve rats.
Animal Model: | Adult male Sprague Dawley rats (240–250 g) |
Dosage: | 3 mg/kg |
Administration: | Injected intraperitoneally; 30 min before U69,593 administration |
Result: | Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-naïve rats. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-135230 | LY2444296 | 1 mg | 270元 | |
2024/08/19 | HY-135230 | 1346133-11-6 LY2444296 | 1346133-11-6 | 5mg | 700元 |