Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:Chlorproguanil CAS:537-21-3 Package:500Mg,50Mg
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Company Name: |
Chemsky (shanghai) International Co.,Ltd
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Tel: |
021-50135380 |
Email: |
shchemsky@sina.com |
Products Intro: |
Product Name:Chlorproguanil;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;
1-(3,4-Dichlorophenyl)-5-isopropylbiguanide; Chloroproguanil; N1-3,4-Dichlorophenyl-N5-isopropyldiguanide; M 5943 CAS:537-21-3 Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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Company Name: |
Energy Chemical
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Tel: |
021-58432009 400-005-6266 |
Email: |
marketing@energy-chemical.com |
Products Intro: |
Product Name:Chlorproguanil CAS:537-21-3 Purity:NULL Package:500mg;50mg Remarks:NULL
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| PROGUANIL HYDROCHLORIDE Basic information |
Product Name: | PROGUANIL HYDROCHLORIDE | Synonyms: | PROGUANIL HYDROCHLORIDE;1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;Chloroproguanil;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-;M-5943 | CAS: | 537-21-3 | MF: | C11H15Cl2N5 | MW: | 288.18 | EINECS: | 208-660-3 | Product Categories: | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | Mol File: | 537-21-3.mol | |
| PROGUANIL HYDROCHLORIDE Chemical Properties |
Melting point | 120-121 °C | Boiling point | 350.7±52.0 °C(Predicted) | density | 1.40±0.1 g/cm3(Predicted) | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 10.77±0.10(Predicted) | color | White to Off-White | BCS Class | 1 | Stability: | Hygroscopic |
| PROGUANIL HYDROCHLORIDE Usage And Synthesis |
Uses | PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250). | Definition | ChEBI: Chlorproguanil is a dichlorobenzene. | Clinical Use | Malaria chemoprophylaxis | Drug interactions | Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine. | Metabolism | Proguanil is metabolised in the liver to the active
metabolite, cycloguanil, and to p-chlorophenylbiguanide
which is inactive, mainly by cytochrome P450, CYP
2C19 and slightly by CYP 3A4. Unlike proguanil and
p-chlorophenylbiguanide, cycloguanil is not concentrated
in erythrocytes so concentrations of cycloguanil in
plasma and whole blood are similar. About 40-60% of
a dose of proguanil is excreted in the urine, 60% of this
as the unchanged drug, 30% as cycloguanil, and 8% as
p-chlorophenylbiguanide. About 10% of a dose is excreted
in the faeces. |
| PROGUANIL HYDROCHLORIDE Preparation Products And Raw materials |
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