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PROGUANIL HYDROCHLORIDE

PROGUANIL HYDROCHLORIDE Suppliers list
Company Name: Shaanxi Didu New Materials Co. Ltd
Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Products Intro: Product Name:537-21-3;Chlorproguanil
CAS:537-21-3
Purity:0.99 Package:25KG,200L
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:Chlorproguanil
CAS:537-21-3
Package:500Mg,50Mg
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:Chlorproguanil;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide; 1-(3,4-Dichlorophenyl)-5-isopropylbiguanide; Chloroproguanil; N1-3,4-Dichlorophenyl-N5-isopropyldiguanide; M 5943
CAS:537-21-3
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Products Intro: Product Name:Chlorproguanil
CAS:537-21-3
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Email: marketing@energy-chemical.com
Products Intro: Product Name:Chlorproguanil
CAS:537-21-3
Purity:NULL Package:500mg;50mg Remarks:NULL
PROGUANIL HYDROCHLORIDE Basic information
Product Name:PROGUANIL HYDROCHLORIDE
Synonyms:PROGUANIL HYDROCHLORIDE;1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;Chloroproguanil;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-;M-5943
CAS:537-21-3
MF:C11H15Cl2N5
MW:288.18
EINECS:208-660-3
Product Categories:Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:537-21-3.mol
PROGUANIL HYDROCHLORIDE Structure
PROGUANIL HYDROCHLORIDE Chemical Properties
Melting point 120-121 °C
Boiling point 350.7±52.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka10.77±0.10(Predicted)
color White to Off-White
BCS Class1
Stability:Hygroscopic
Safety Information
MSDS Information
PROGUANIL HYDROCHLORIDE Usage And Synthesis
UsesPROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
DefinitionChEBI: Chlorproguanil is a dichlorobenzene.
Clinical UseMalaria chemoprophylaxis
Drug interactionsPotentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with artemether/lumefantrine; increased antifolate effect with pyrimethamine.
MetabolismProguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.
PROGUANIL HYDROCHLORIDE Preparation Products And Raw materials
Tag:PROGUANIL HYDROCHLORIDE(537-21-3) Related Product Information
Verapamil N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE 3-Chlorophenylguanidine 1-(3-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE Chlorguanide Hydrochloride N-(3,4-Dichlorophenyl)guanidine PROGUANIL HYDROCHLORIDE