| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Cylindrospermopsin
CAS:143545-90-8
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Cylindrospermopsin
CAS:143545-90-8
Purity:≥95% Remarks:It is produced by the strain of Cylindrospermopsis raciborskii. Cylindrospermopsin is a tricyclic uracil derivative which is a cyanobacterial toxin. And it targets protein and glutathione synthesis in
|
|
| | CYLINDROSPERMOPSIN Basic information |
| Product Name: | CYLINDROSPERMOPSIN | | Synonyms: | 6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione;2,4(1h,3h)-pyrimidinedione,6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(;5a-alpha,7-beta(r*))-(-)-h;cylindrospermopsin;sulfooxy)-1h-1,8,8b-triazaacenaphthylen-7-yl)methyl)-,(2a-alpha,3-alpha,4-alp;PubChem ID: 42628600;2,4(1H,3H)-Pyrimidinedione, 6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]- | | CAS: | 143545-90-8 | | MF: | C15H21N5O7S | | MW: | 415.42 | | EINECS: | | | Product Categories: | | | Mol File: | 143545-90-8.mol |  |
| | CYLINDROSPERMOPSIN Chemical Properties |
| density | 1.3937 (rough estimate) | | refractive index | 1.6460 (estimate) | | storage temp. | −20°C | | solubility | DMSO: soluble | | form | white powder | | pka | -3.78±0.18(Predicted) | | EPA Substance Registry System | Cylindrospermopsin (143545-90-8) |
| WGK Germany | 3 | | RTECS | UV9104310 | | Hazardous Substances Data | 143545-90-8(Hazardous Substances Data) | | Toxicity | mouse,LD50,intraperitoneal,2100ug/kg (2.1mg/kg),LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"BLOOD: CHANGES IN SPLEENKIDNEY, URETER, AND BLADDER: OTHER CHANGES,Toxicologist. Vol. 14, Pg. 211, 1994. |
| | CYLINDROSPERMOPSIN Usage And Synthesis |
| Description | Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 μg/ml. | | Uses | Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water. | | Definition | ChEBI: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respecti
ely (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species
f freshwater cyanobacteria, such as Aphanizomenon ovalisporum. |
| | CYLINDROSPERMOPSIN Preparation Products And Raw materials |
|