DJ001 manufacturers
- DJ001
-
- $58.00 / 1mg
-
2024-11-12
- CAS:2161305-12-8
- Min. Order:
- Purity: 98.21%
- Supply Ability: 10g
- DJ001
-
- $58.00 / 1mg
-
2024-11-12
- CAS:2161305-12-8
- Min. Order:
- Purity: 98.21%
- Supply Ability: 10g
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| Product Name: | DJ001 | | Synonyms: | DJ001;DJ-001,DJ001;2-Propen-1-one, 3-[(3-nitrophenyl)amino]-1-phenyl-, (2Z)- | | CAS: | 2161305-12-8 | | MF: | C15H12N2O3 | | MW: | 268.27 | | EINECS: | | | Product Categories: | | | Mol File: | 2161305-12-8.mol |  |
| | DJ001 Chemical Properties |
| Boiling point | 417.7±45.0 °C(Predicted) | | density | 1.297±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming) | | form | solid | | pka | -1.30±0.70(Predicted) | | color | Yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | DJ001 Usage And Synthesis |
| Description | DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTPσ) IC50=1.54 μM and >10 μM for 20 other phosphatases.1? Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouracil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTPs is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1 | | References | References/Citations: |
| | DJ001 Preparation Products And Raw materials |
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