DJ001
| 中文名称 | DJ001 |
|---|---|
| 中文同义词 | 化合物 T11053;化合物DJ001 |
| 英文名称 | DJ001 |
| 英文同义词 | DJ001;DJ-001,DJ001;2-Propen-1-one, 3-[(3-nitrophenyl)amino]-1-phenyl-, (2Z)- |
| CAS号 | 2161305-12-8 |
| 分子式 | C15H12N2O3 |
| 分子量 | 268.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2161305-12-8.mol |
| 结构式 |  |
DJ001 性质
| 沸点 | 417.7±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.297±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 溶于 DMSO（最高 50 mg/ml）或乙醇（升温最高 10 mg/ml） |
| 形态 | 固体 |
| 酸度系数(pKa) | -1.30±0.70(Predicted) |
| 颜色 | 粘黄色 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达3个月。 |
IC50: 1.43 μM (Protein tyrosine phosphatase-σ)
DJ001 (5-1000 ng/mL; 3-7 days; BM KSL cells) treatment increases the percentages and numbers of BM KSL cells in culture compared with control cultures. DJ001 treatment also significantly increases the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells.
The BM KSL cells are irradiated with 300 cGy and placed in media (containing 20 ng/mL Thrombopoietin, 100 ng/mL stem cell factor (SCF), 50 ng/mL Flt3 ligand, TSF) with and without 1 μg/mL DJ001 for 3 days. DJ001 treatment increases recovery of BM CFCs and multipotent colony-forming unit–granulocyte erythroid monocyte megakaryocyte (CFU-GEMM) colonies compared with control cultures.
Cell Viability Assay
| Cell Line: | BM KSL cells |
| Concentration: | 5 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL |
| Incubation Time: | 3 days or 7 days |
| Result: | Increased the percentages and numbers of BM KSL cells. Also significantly increased the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells. |
DJ001 (5 mg/kg; subcutaneous injection; for 24 hours; female C57BL/6 mice) significantly decreases the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI. DJ001 suppresses radiation-induced HSC apoptosis via activation of the RhoGTPase, RAC1, and induction of BCL-X L .
| Animal Model: | Female C57BL/6 mice (8-10-week-old) irradiated with total body irradiation (TBI) |
| Dosage: | 5 mg/kg |
| Administration: | Subcutaneous injection; for 24 hours |
| Result: | Significantly decreased the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-133146 | DJ001 | 1 mg | 1200元 | |
| 2024/11/08 | HY-133146 | DJ001 DJ001 | 2161305-12-8 | 5mg | 2800元 |